| Literature DB >> 6318744 |
L S Chia, J E Thompson, M A Moscarello.
Abstract
Potassium superoxide (KO.2), applied as a source of superoxide radical directly in vitro to white matter from young adult human brain, caused the lipid phase of the myelin to change from a crystalline (ordered) state to a liquid crystalline (disordered) state. The myelin transition temperature decreased from 65 degrees C to 37 degrees C. This alteration was accompanied by a dramatic increase in the levels of lipid peroxidation products--malondialdehyde, a conjugated diene, and ethane. These changes in human myelin, induced by direct application of O2-. radical, simulated myelin deterioration that occurs in the course of natural aging, thus, providing further substantiation for the notion that O2-. might be a major toxic agent associated with the aging process.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6318744 DOI： 10.1016/0006-291x(83)91552-8
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575