Literature DB >> 6318743

Isolation and characterization of a human interleukin 2 gene.

S Mita, S Maeda, K Obaru, N Nishino, K Shimada, T Hirano, K Onoue, T Ogawa, H Ogawa.   

Abstract

An interleukin 2 (IL-2) gene was isolated from a Charon 4A human gene library. Electron microscopic examination of 15 heteroduplexes formed between the genomic DNAs and the IL-2 cDNAs demonstrated that the size of the IL-2 gene is about 5.1 +/- 0.5 kb and that there are at least two introns in this gene. Nucleotide sequence of the 5' flanking region of the IL-2 gene showed a homology with that of the corresponding region of the human immune interferon gene.

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Year:  1983        PMID: 6318743     DOI: 10.1016/0006-291x(83)91548-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  3 in total

1.  Cytokine gene expression in normal human lymphocytes in response to stimulation.

Authors:  J Fan; P Nishanian; E C Breen; M McDonald; J L Fahey
Journal:  Clin Diagn Lab Immunol       Date:  1998-05

2.  Lymphocyte infiltration of the skin in transgenic mice carrying the human interleukin-2 gene.

Authors:  M Akiyama; M Yokoyama; M Katsuki; S Habu; T Nishikawa
Journal:  Arch Dermatol Res       Date:  1993       Impact factor: 3.017

3.  Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

Authors:  A Granelli-Piperno; L Andrus; R M Steinman
Journal:  J Exp Med       Date:  1986-04-01       Impact factor: 14.307

  3 in total

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