Literature DB >> 6318396

Rat liver microsomal transformation of ethene to oxirane in vitro.

G Schmiedel, J G Filser, H M Bolt.   

Abstract

Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

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Year:  1983        PMID： 6318396     DOI： 10.1016/0378-4274(83)90133-9

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  7 in total

1.  Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation.

Authors:  G Johanson; J G Filser
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

2.  Kinetics and disposition in toxicology. Example: carcinogenic risk estimate for ethylene.

Authors:  H M Bolt; J G Filser
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

3.  Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene.

Authors:  J G Filser; B Denk; M Törnqvist; W Kessler; L Ehrenberg
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

4.  Inhalation pharmacokinetics based on gas uptake studies. V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats.

Authors:  H M Bolt; J G Filser; F Störmer
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153

5.  Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153

6.  Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers.

Authors:  Qiang Li; György András Csanády; Winfried Kessler; Dominik Klein; Helmut Pankratz; Christian Pütz; Nadine Richter; Johannes Georg Filser
Journal:  Toxicol Sci       Date:  2011-07-23       Impact factor: 4.849

7.  Ethylene oxide in blood of ethylene-exposed B6C3F1 mice, Fischer 344 rats, and humans.

Authors:  Johannes Georg Filser; Winfried Kessler; Anna Artati; Eva Erbach; Thomas Faller; Paul Erich Kreuzer; Qiang Li; Josef Lichtmannegger; Wanwiwa Numtip; Dominik Klein; Christian Pütz; Brigitte Semder; György András Csanády
Journal:  Toxicol Sci       Date:  2013-09-25       Impact factor: 4.849
  7 in total

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