Literature DB >> 6318313

Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: potentiation by chloroquine.

S Ramakrishnan, L L Houston.   

Abstract

Immunotoxins containing pokeweed antiviral protein and monoclonal antibodies against human T cells or human transferrin receptor efficiently killed acute lymphoblastic leukemia cells. Chloroquine specifically enhanced the rate of protein synthesis inhibition by immunotoxin. Depending on its concentration, chloroquine (10 to 100 micromolar) reduced by up to 65-fold the amount of immunotoxin required to inhibit protein synthesis in the target cells 50 percent.

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Year:  1984        PMID： 6318313     DOI： 10.1126/science.6318313

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  The in-vitro inhibition of rat alloantigen presentation by immunotoxins--implications for allografting.

Authors:  K N Wiley; A Clark; M Fox
Journal:  Clin Exp Immunol       Date:  1989-04       Impact factor: 4.330

2.  Synthesis, characterization and biological activity of trans-platinum(II) complexes with chloroquine.

Authors:  Maribel Navarro; William Castro; Angel R Higuera-Padilla; Anibal Sierraalta; María Jesús Abad; Peter Taylor; Roberto A Sánchez-Delgado
Journal:  J Inorg Biochem       Date:  2011-09-22       Impact factor: 4.155

3.  Different cytotoxic activity and intracellular fate of an anti-CD5-momordin immunotoxin in normal compared to tumour cells.

Authors:  G Porro; P Lento; F Marcucci; G Gromo; D Modena
Journal:  Cancer Immunol Immunother       Date:  1995-04       Impact factor: 6.968

Review 4.  Immunotoxins against solid tumors.

Authors:  R Pirker
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 5.  The transferrin receptor and the targeted delivery of therapeutic agents against cancer.

Authors:  Tracy R Daniels; Ezequiel Bernabeu; José A Rodríguez; Shabnum Patel; Maggie Kozman; Diego A Chiappetta; Eggehard Holler; Julia Y Ljubimova; Gustavo Helguera; Manuel L Penichet
Journal:  Biochim Biophys Acta       Date:  2011-08-05

6.  Human immunodeficiency virus-infected T cells and monocytes are killed by monoclonal human anti-gp41 antibodies coupled to ricin A chain.

Authors:  M A Till; S Zolla-Pazner; M K Gorny; J S Patton; J W Uhr; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

7.  An immunotoxin containing a rat IgM monoclonal antibody (Campath 1) and saporin 6: effect on T lymphocytes and hemopoietic cells.

Authors:  P L Tazzari; L Barbieri; M Gobbi; A Dinota; S Rizzi; A Bontadini; A Pession; S Tura; F Stirpe
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

Review 8.  Myasthenia gravis--current concepts.

Authors:  C Herrmann; J M Lindstrom; J C Keesey; D G Mulder
Journal:  West J Med       Date:  1985-06

9.  Cross linking of anti-B16 melanoma monoclonal antibodies to lymphokine activated killer (LAK) cells: possible role in the therapy of B16 melanoma.

Authors:  A Eisenthal; S A Rosenberg
Journal:  Clin Exp Metastasis       Date:  1988 Sep-Oct       Impact factor: 5.150

10.  In vitro synergism between hybrid immunotoxins and chemotherapeutic drugs: relevance to immunotherapy of prostate carcinoma.

Authors:  K S Webb; S N Liberman; J L Ware; P J Walther
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968
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