Literature DB >> 6318187

The efficacy of agonists at the frog neuromuscular junction studied with single channel recording.

D C Ogden, D Colquhoun.   

Abstract

The efficacy of acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction was estimated by single channel recording. The probability of channel opening at high concentration was found to be greater than 0.9 for each, thus showing (a) that their efficacy is high and (b) that the opening rate for the fully-liganded channel is higher than previously thought.

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Year:  1983        PMID： 6318187     DOI： 10.1007/bf00656725

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  9 in total

1.  Interaction at end-plate receptors between different choline derivatives.

Authors:  J DEL CASTILLO; B KATZ
Journal:  Proc R Soc Lond B Biol Sci       Date:  1957-05-07

2.  A modification of receptor theory.

Authors:  R P STEPHENSON
Journal:  Br J Pharmacol Chemother       Date:  1956-12

3.  Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions.

Authors:  W Betz; B Sakmann
Journal:  J Physiol       Date:  1973-05       Impact factor: 5.182

4.  Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels.

Authors:  D Colquhoun; B Sakmann
Journal:  Nature       Date:  1981-12-03       Impact factor: 49.962

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

Review 6.  Acetylcholine receptor kinetics.

Authors:  P R Adams
Journal:  J Membr Biol       Date:  1981-02-28       Impact factor: 1.843

Review 7.  Acetylcholine receptor-controlled ion translocation: chemical kinetic investigations of the mechanism.

Authors:  G P Hess; D J Cash; H Aoshima
Journal:  Annu Rev Biophys Bioeng       Date:  1983

8.  Kinetic parameters for acetylcholine interaction in intact neuromuscular junction.

Authors:  B R Land; E E Salpeter; M M Salpeter
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

9.  Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist.

Authors:  B Sakmann; J Patlak; E Neher
Journal:  Nature       Date:  1980-07-03       Impact factor: 49.962
  9 in total
  12 in total

Review 1.  Activation of skeletal muscle nicotinic acetylcholine receptors.

Authors:  C J Lingle; D Maconochie; J H Steinbach
Journal:  J Membr Biol       Date:  1992-03       Impact factor: 1.843

2.  Direct measurement of the concentration- and time-dependent open probability of the nicotinic acetylcholine receptor channel.

Authors:  J P Dilger; R S Brett
Journal:  Biophys J       Date:  1990-04       Impact factor: 4.033

3.  Chemical kinetic measurements of a mammalian acetylcholine receptor by a fast-reaction technique.

Authors:  J B Udgaonkar; G P Hess
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

4.  Two types of acetylcholine receptor channels in developing Xenopus muscle cells in culture: further kinetic analyses.

Authors:  Y Igusa; Y Kidokoro
Journal:  J Physiol       Date:  1987-08       Impact factor: 5.182

5.  The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle.

Authors:  C G Marshall; D C Ogden; D Colquhoun
Journal:  J Physiol       Date:  1990-09       Impact factor: 5.182

6.  Further kinetic analysis of the chemically modified acetylcholine receptor.

Authors:  A Steinacker; C Zuazaga
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

7.  Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs.

Authors:  L D Chabala; A M Gurney; H A Lester
Journal:  Biophys J       Date:  1985-08       Impact factor: 4.033

8.  Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate.

Authors:  D Colquhoun; B Sakmann
Journal:  J Physiol       Date:  1985-12       Impact factor: 5.182

9.  Variance analysis of gamma-aminobutyric acid (GABA)-ergic inhibitory postsynaptic currents from melanotropes of Xenopus laevis.

Authors:  J G Borst; K S Kits; M Bier
Journal:  Biophys J       Date:  1994-07       Impact factor: 4.033

10.  Activation of ion channels in the frog end-plate by high concentrations of acetylcholine.

Authors:  D Colquhoun; D C Ogden
Journal:  J Physiol       Date:  1988-01       Impact factor: 5.182
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