Literature DB >> 6318117

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse.

P M Brickell, D S Latchman, D Murphy, K Willison, P W Rigby.   

Abstract

A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.

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Year:  1983        PMID： 6318117     DOI： 10.1038/306756a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  53 in total

Review 1.  RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.

Authors:  T R Brown; P H Scott; T Stein; A G Winter; R J White
Journal:  Gene Expr       Date:  2000

2.  Physical mapping of the MHC and grc by pulse field electrophoresis.

Authors:  D Vardimon; J Locker; H W Kunz; T J Gill
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

Review 3.  Class I genes and molecules: an update.

Authors:  A M Lew; E P Lillehoj; E P Cowan; W L Maloy; M R van Schravendijk; J E Coligan
Journal:  Immunology       Date:  1986-01       Impact factor: 7.397

4.  Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail.

Authors:  D Grossberger; W Hein; A Marcuz
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

5.  Organization and regulation of an operon that encodes a sporulation-essential sigma factor in Bacillus subtilis.

Authors:  T J Kenney; C P Moran
Journal:  J Bacteriol       Date:  1987-07       Impact factor: 3.490

6.  Detection of alternative splicing during epithelial-mesenchymal transition.

Authors:  Huilin Huang; Yilin Xu; Chonghui Cheng
Journal:  J Vis Exp       Date:  2014-10-09       Impact factor: 1.355

7.  Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.

Authors:  D S Latchman; J K Estridge; L M Kemp
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

8.  The structure of HSAG-1, a middle repetitive genetic element which elicits a leukemia-related cellular surface antigen.

Authors:  J W Chamberlain; G Henderson; M W Chang; T Lam; D Dignard; V Ling; G B Price; C P Stanners
Journal:  Nucleic Acids Res       Date:  1986-04-25       Impact factor: 16.971

9.  Functional role of HLA class I cell-surface molecules in human T-lymphocyte activation and proliferation.

Authors:  D S Taylor; P C Nowell; J Kornbluth
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

10.  A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice.

Authors:  B St-Jacques; T H Han; A MacMurray; H S Shin
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272
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