Literature DB >> 6317432

Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effects of ascorbate on ATPase activity.

T Kitao, K Hattori.   

Abstract

We studied the effect of aclacinomycin on human erythrocyte membrane enzymes. Aclacinomycin inhibited ATPase, including Na-K-dependent ATPase, ouabain insensitive ATPase and Ca-ATPase. However acetylcholinesterase was not inhibited by aclacinomycin. The ATPase activities were not inhibited by aclacinomycin if ascorbate was added to the incubation mixture. However other reducing agents, alpha-tocopherol, superoxide dismutase and catalase had no effect on ATPase activity. Ascorbate may protect membrane proteins and lipids from peroxidate damage.

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Year:  1983        PMID： 6317432     DOI： 10.1007/bf01990105

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.

Authors:  J T DODGE; C MITCHELL; D J HANAHAN
Journal:  Arch Biochem Biophys       Date:  1963-01       Impact factor: 4.013

2.  Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.

Authors:  J Goodman; P Hochstein
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3.  Clinical study of aclacinomycin A.

Authors:  M Ogawa; J Inagaki; N Horikoshi; K Inoue; T Chinen; H Ueoka; E Nagura
Journal:  Cancer Treat Rep       Date:  1979-05

4.  International Committee for Standardization in Haematology: recommended methods for red-cell enzyme analysis.

Authors:  E Beutler; K G Blume; J C Kaplan; G W Löhr; B Ramot; W N Valentine
Journal:  Br J Haematol       Date:  1977-02       Impact factor: 6.998

5.  The effects of adriamycin (doxorubicin HCl) on human red blood cells.

Authors:  K Shinohara; K R Tanaka
Journal:  Hemoglobin       Date:  1980       Impact factor: 0.849

6.  Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.

Authors:  C A Henderson; E N Metz; S P Balcerzak; A L Sagone
Journal:  Blood       Date:  1978-11       Impact factor: 22.113
  6 in total
  4 in total

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Journal:  Mol Cell Biochem       Date:  1995-10-04       Impact factor: 3.396

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Authors:  Alessandro Ghezzo; Paola Visconti; Provvidenza M Abruzzo; Alessandra Bolotta; Carla Ferreri; Giuseppe Gobbi; Gemma Malisardi; Stefano Manfredini; Marina Marini; Laura Nanetti; Emanuela Pipitone; Francesca Raffaelli; Federica Resca; Arianna Vignini; Laura Mazzanti
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4.  Association between a novel G94A single nucleotide polymorphism in ATP1A1 gene and type 2 diabetes mellitus among Egyptian patients.

Authors:  Mohammed A Abosheasha; Faten Zahran; Sahar S Bessa; Mohammed A El-Magd; Tarek M Mohamed
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  4 in total

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