Literature DB >> 6317416

Codepletion of serotonin and TRH induces apparent supersensitivity of spinal TRH receptors.

N A Sharif, D R Burt, A C Towle, R A Mueller, G R Breese.   

Abstract

Thyrotropin-releasing hormone (TRH), substance P (SP) and serotonin (5-HT) coexist in raphe efferents to the spinal cord. Lesions of these serotonergic projections by intracisternal injection of 5,7-dihydroxytryptamine (50 micrograms) in rat pups resulted in 93% and 65% decreases in 5-HT and TRH content of adult rat spinal cords, respectively. This codepletion induced a 30-40% increase in binding of [3H][3-Me-His2]TRH [( 3H]MeTRH) to TRH receptors. The affinity and pharmacological specificity of [3H]MeTRH binding to control and DHT-lesioned cords appeared closely similar.

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Year:  1983        PMID： 6317416     DOI： 10.1016/0014-2999(83)90651-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Changes in the behavioural response to a TRH analogue following chronic amitriptyline treatment and repeated electroconvulsive shock in the rat.

Authors:  G W Bennett; A R Green; C Lighton; C A Marsden
Journal:  Br J Pharmacol       Date:  1986-05       Impact factor: 8.739

2.  Proceedings of the British Pharmacological Society. University of Dundee, 11th-14th September, 1984. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1984-12       Impact factor: 8.739

3.  Proceedings of the British Pharmacological Society. 11th-13th April, 1984. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739

4.  Involvement of 5-HT2 receptors in the behaviours produced by intrathecal administration of selected 5-HT agonists and the TRH analogue (CG 3509) to rats.

Authors:  K C Fone; J V Johnson; G W Bennett; C A Marsden
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

5.  Some regional anatomical relationships of TRH to 5-HT in rat limbic forebrain.

Authors:  A Sattin; M J Kubek; W C Low; C J Staley; J R Simon
Journal:  Neurochem Res       Date:  1992-05       Impact factor: 3.996

6.  Early postnatal administration of 5,7-dihydroxytryptamine: effects on substance P and thyrotropin-releasing hormone neurons and terminals in rat brain.

Authors:  A C Towle; G R Breese; R A Mueller; R Hunt; J M Lauder
Journal:  Brain Res       Date:  1986-01-15       Impact factor: 3.252
  6 in total

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