| Literature DB >> 6317397 |
M Saeed, J Holtz, D Elsner, E Bassenge.
Abstract
The effects of nifedipine on hindlimb vasoconstriction caused by norepinephrine infusion and sympathetic stimulation (0.1-1.0 Hz) were compared in dogs given 0.12 mg/kg prazosin or 0.3 mg/kg rauwolscine. Constrictions due to stimulation or norephinephrine with prazosin, presumed to be mediated by vascular alpha 2-adrenoceptors, were significantly attenuated by 30 micrograms/kg nifedipine, while constrictions with rauwolscine, presumably alpha 1-mediated, remained unaffected. These data support the hypothesis that the antihypertensive effect of calcium antagonists is based upon interference with alpha 2-mediated sympathetic vasoconstriction.Entities:
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Year: 1983 PMID： 6317397 DOI： 10.1016/0014-2999(83)90453-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432