Literature DB >> 6316858

Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis.

E M Davidson, S A Rae, M J Smith.   

Abstract

Leukotriene B4 (LTB4), generated from arachidonic acid following lipoxygenase activity by a variety of inflammatory leucocytes, has been shown to be present in synovial fluid from patients with active rheumatoid arthritis. It does not persist as such, being converted to less active metabolites. The role of LTB4 as one of the natural mediators of inflammation is discussed.

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Year:  1983        PMID： 6316858      PMCID： PMC1001328          DOI： 10.1136/ard.42.6.677

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  8 in total

1.  Leukotriene B4 in synovial fluid.

Authors:  E M Davidson; S A Rae; M J Smith
Journal:  J Pharm Pharmacol       Date:  1982-06       Impact factor: 3.765

2.  Aggregation of rat polymorphonuclear leucocytes in vitro.

Authors:  F M Cunningham; M E Shipley; M J Smith
Journal:  J Pharm Pharmacol       Date:  1980-05       Impact factor: 3.765

3.  Leukotriene B4: an inflammatory mediator in vivo.

Authors:  M A Bray; A W Ford-Hutchinson; M J Smith
Journal:  Prostaglandins       Date:  1981-08

4.  Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes.

Authors:  G Hansson; J A Lindgren; S E Dahlén; P Hedqvist; B Samuelsson
Journal:  FEBS Lett       Date:  1981-07-20       Impact factor: 4.124

5.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

6.  Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.

Authors:  A W Ford-Hutchinson; M A Bray; M V Doig; M E Shipley; M J Smith
Journal:  Nature       Date:  1980-07-17       Impact factor: 49.962

7.  Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica.

Authors:  W S Powell
Journal:  Prostaglandins       Date:  1980-11

8.  Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

Authors:  L B Klickstein; C Shapleigh; E J Goetzl
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808
  8 in total
  45 in total

Review 1.  The measurement of leukotrienes in human fluids.

Authors:  J Y Westcott
Journal:  Clin Rev Allergy Immunol       Date:  1999 Spring-Summer       Impact factor: 8.667

2.  Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.

Authors:  Carla Carbo; Daniel Duerschmied; Tobias Goerge; Hidenori Hattori; Jiro Sakai; Stephen M Cifuni; Gilbert C White; Magdalena Chrzanowska-Wodnicka; Hongbo R Luo; Denisa D Wagner
Journal:  J Leukoc Biol       Date:  2010-04-22       Impact factor: 4.962

3.  Enhanced capacity for release of leucotriene B4 by neutrophils in rheumatoid arthritis.

Authors:  J Elmgreen; O H Nielsen; I Ahnfelt-Rønne
Journal:  Ann Rheum Dis       Date:  1987-07       Impact factor: 19.103

4.  Tolfenamic acid inhibits leukotriene B4-induced chemotaxis of polymorphonuclear leukocytes in vitro.

Authors:  H Kankaanranta; E Moilanen; H Vapaatalo
Journal:  Inflammation       Date:  1991-04       Impact factor: 4.092

5.  LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats.

Authors:  Wen Yang; Xia Wang; Liuxin Xu; Honglin Li; Rui Wang
Journal:  Am J Transl Res       Date:  2018-08-15       Impact factor: 4.060

6.  Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis.

Authors:  Federico Díaz-González; Rieke H E Alten; William G Bensen; Jacques P Brown; John T Sibley; Maxime Dougados; Stefano Bombardieri; Patrick Durez; Pablo Ortiz; Gonzalo de-Miquel; Alexander Staab; Ralf Sigmund; Laurence Salin; Caroline Leledy; Stephen H Polmar
Journal:  Ann Rheum Dis       Date:  2006-12-14       Impact factor: 19.103

7.  Orally administered tolfenamic acid inhibits leukotriene synthesis in isolated human peripheral polymorphonuclear leukocytes.

Authors:  E Moilanen; J Alanko; A Juhakoski; H Vapaatalo
Journal:  Agents Actions       Date:  1989-08

8.  Eicosanoid production in rheumatoid synovitis.

Authors:  E Moilanen; J Alanko; M Nissilä; M Hämäläinen; H Isomäki; H Vapaatalo
Journal:  Agents Actions       Date:  1989-11

9.  A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.

Authors:  Hisako Hikiji; Satoshi Ishii; Takehiko Yokomizo; Tsuyoshi Takato; Takao Shimizu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-24       Impact factor: 11.205

10.  Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.

Authors:  Karina Roxana Gheorghe; Marina Korotkova; Anca Irinel Catrina; Linda Backman; Erik af Klint; Hans-Erik Claesson; Olof Rådmark; Per-Johan Jakobsson
Journal:  Arthritis Res Ther       Date:  2009-06-04       Impact factor: 5.156
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