Demonstration of human papilloma virus (HPV) antigens in a case of urethral condyloma.

A 33-year-old women is reported, in whom a urethral condyloma was found 2 years after a preceding condylomatous lesion in the uterine cervix. The urethral condyloma was of the flat type, not previously described in this location, and it was found by an indirect immunoperoxidase-PAP method to contain cells positive for human papilloma virus (HPV) antigens. The role of HPV in the etiology of such condylomas is briefly reviewed and the suggested involvement of HPV in human squamous cell carcinogenesis is discussed.