Literature DB >> 6315946

Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs.

G Goldberg, D Mochly-Rosen, S Fuchs, Y Lass.   

Abstract

Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.

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Year:  1983        PMID： 6315946     DOI： 10.1007/bf02000612

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  35 in total

1.  Acetylcholine receptors.

Authors:  D P Green; R Miledi; M Perez de la Mora; A Vincent
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1975-06-10       Impact factor: 6.237

2.  A transition temperature for acetylcholine channel conductance in chick myoballs.

Authors:  G D Fischbach; Y Lass
Journal:  J Physiol       Date:  1978-07       Impact factor: 5.182

3.  Direct structural localization of two toxin-recognition sites on an ACh receptor protein.

Authors:  H P Zingsheim; F J Barrantes; J Frank; W Hänicke; D C Neugebauer
Journal:  Nature       Date:  1982-09-02       Impact factor: 49.962

4.  Diffusion of acetylcholine in the synaptic cleft of normal and myasthenia gravis human endplates.

Authors:  S G Cull-Candy; R Miledi; O D Uchitel
Journal:  Nature       Date:  1980-07-31       Impact factor: 49.962

5.  Acetylcholine-induced conductance fluctuations in cultured human myotubes.

Authors:  S Bevan; R W Kullberg; J Rice
Journal:  Nature       Date:  1978-06-08       Impact factor: 49.962

6.  Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site.

Authors:  D Mochly-Rosen; S Fuchs
Journal:  Biochemistry       Date:  1981-09-29       Impact factor: 3.162

7.  Independent activation of the acetylcholine receptor from Torpedo californica at two sites.

Authors:  A M Delegeane; M G McNamee
Journal:  Biochemistry       Date:  1980-03-04       Impact factor: 3.162

8.  Neuromuscular Transmission in experimental autoimmune myasthenia gravis (EAMG). Quantitative ionophoresis and current fluctuation analysis at normal and myasthenic rat end-plates.

Authors:  R Hohlfeld; R Sterz; I Kalies; K Peper; H Wekerle
Journal:  Pflugers Arch       Date:  1981-05       Impact factor: 3.657

9.  Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.

Authors:  C R Anderson; C F Stevens
Journal:  J Physiol       Date:  1973-12       Impact factor: 5.182

10.  Functional stoichiometry at the nicotinic receptor. The photon cross section for phase 1 corresponds to two bis-Q molecules per channel.

Authors:  R E Sheridan; H A Lester
Journal:  J Gen Physiol       Date:  1982-10       Impact factor: 4.086
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  7 in total

Review 1.  Immunopathologic events at the endplate in myasthenia gravis.

Authors:  T Ashizawa; S H Appel
Journal:  Springer Semin Immunopathol       Date:  1985

2.  Action of antibodies directed against the acetylcholine receptor on channel function at mouse and rat motor end-plates.

Authors:  J O Dolly; M Gwilt; G Lacey; J Newsom-Davis; A Vincent; P Whiting; D W Wray
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

3.  Effects of a monoclonal anti-acetylcholine receptor antibody on the avian end-plate.

Authors:  R A Maselli; D J Nelson; D P Richman
Journal:  J Physiol       Date:  1989-04       Impact factor: 5.182

4.  Effect of sera from seronegative myasthenia gravis patients on neuromuscular junctions.

Authors:  Rumi Sato; Shiho Imamoto; Iku Utsnomiya; Terumasa Chiba; Kyoji Taguchi; Kenji Abe; Keiko Tanaka; Tadashi Miyatake
Journal:  Neurol Sci       Date:  2013-02-07       Impact factor: 3.307

5.  Identification of a hexapeptide that mimics a conformation-dependent binding site of acetylcholine receptor by use of a phage-epitope library.

Authors:  M Balass; Y Heldman; S Cabilly; D Givol; E Katchalski-Katzir; S Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

6.  Activation and blockade of mouse muscle nicotinic channels by antibodies directed against the binding site of the acetylcholine receptor.

Authors:  J Bufler; S Kahlert; S Tzartos; K V Toyka; A Maelicke; C Franke
Journal:  J Physiol       Date:  1996-04-01       Impact factor: 5.182

7.  The control of chick myoblast fusion by ion channels operated by prostaglandins and acetylcholine.

Authors:  A Entwistle; R J Zalin; S Bevan; A E Warner
Journal:  J Cell Biol       Date:  1988-05       Impact factor: 10.539
  7 in total

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