| Literature DB >> 6315939 |
S Archer, A Seyed-Mozaffari, P Osei-Gyimah, J M Bidlack, L G Abood.
Abstract
14 beta-(2-Bromoacetamido)morphine (6) and 14 beta-(2-bromoacetamido)morphinone (9) were prepared preferably from the adduct of thebaine and 1-chloro-1-nitrosocyclohexane, which on reduction in methanol solution gave 14-aminocodeinone (2) and the corresponding ketal (3). When tested in a receptor-binding assay, the IC50 values of 6 and 9 were 15 and 10 nM, respectively. If the incubation time during the assay was increased from 15 to 30 min, irreversible binding of both ligands was observed.Entities:
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Year: 1983 PMID： 6315939 DOI： 10.1021/jm00366a024
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446