Literature DB >> 6315806

Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.

B Ambrosi, D Bochicchio, E Riva, G Faglia.   

Abstract

The effects of the acute administration of sodium-valproate (400 mg po) on plasma ACTH levels were studied in 4 patients with Cushing's disease, 1 with Nelson's syndrome and in 3 with Addison's disease. No significant reduction of corticotropin concentration was observed, as compared to saline infusion. These data do not favor the hypothesis of an inhibitory role of sodium-valproate on ACTH secretion in such patients.

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Year:  1983        PMID： 6315806     DOI： 10.1007/BF03347595

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  6 in total

1.  Biochemical effects in man and rat of three drugs which can increase brain GABA content.

Authors:  T L Perry; S Hansen
Journal:  J Neurochem       Date:  1978-04       Impact factor: 5.372

2.  Possible role of gamma-aminobutyric acid synthesis in the mechanism of dexamethasone feedback action.

Authors:  Z Acs; E Stark
Journal:  J Endocrinol       Date:  1978-04       Impact factor: 4.286

3.  Neurotransmitter regulation of corticotropin-releasing factor in vitro.

Authors:  M T Jones; E W Hillhouse
Journal:  Ann N Y Acad Sci       Date:  1977-10-28       Impact factor: 5.691

4.  Valproate in Cushing's syndrome.

Authors:  B Allolio; W Winkelmann; D Kaulen; F X Hipp; R Mies
Journal:  Lancet       Date:  1982-01-16       Impact factor: 79.321

5.  Effect of treatment with sodium valproate and diazepam on plasma corticotropin in Nelson's syndrome.

Authors:  M T Jones; B Gillham; U Beckford; A Dornhorst; R R Abraham; M Seed; V Wynn
Journal:  Lancet       Date:  1981-05-30       Impact factor: 79.321

6.  Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.

Authors:  A N Elias; G Gwinup; L J Valenta
Journal:  Clin Endocrinol (Oxf)       Date:  1981-08       Impact factor: 3.478
  6 in total
  4 in total

Review 1.  The Treatment of Cushing's Disease.

Authors:  Rosario Pivonello; Monica De Leo; Alessia Cozzolino; Annamaria Colao
Journal:  Endocr Rev       Date:  2015-06-11       Impact factor: 19.871

2.  Failure of long-term therapy with sodium valproate in Cushing's disease.

Authors:  A Colao; R Pivonello; F S Tripodi; F Orio; D Ferone; G Cerbone; C Di Somma; B Merola; G Lombardi
Journal:  J Endocrinol Invest       Date:  1997 Jul-Aug       Impact factor: 4.256

3.  The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease.

Authors:  M Reincke; B Allolio; D Kaulen; C Jaursch-Hancke; W Winkelmann
Journal:  Klin Wochenschr       Date:  1988-08-01

4.  A prospective longitudinal study of Pasireotide in Nelson's syndrome.

Authors:  Eleni Daniel; Miguel Debono; Sharon Caunt; Constantine Girio-Fragkoulakis; Stephen J Walters; Scott A Akker; Ashley B Grossman; Peter J Trainer; John Newell-Price
Journal:  Pituitary       Date:  2018-06       Impact factor: 4.107
  4 in total

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