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Literature DB >> 6315593

Effect of Clostridium perfringens epsilon toxin on the cardiovascular system of rats.

Abstract

Pressor activity was demonstrated by the intravenous injection of purified epsilon toxin of Clostridium perfringens type D but not by that of epsilon prototoxin. The activity was completely abolished by C. perfringens type B or D antiserum, but not by type A, C, or E antiserum. The rise in blood pressure caused by the toxin was accompanied by a decrease in the blood flow in skin without any change of heart rate and electrocardiogram readings. These results indicate that epsilon toxin possesses pressor activity as well as lethal and dermonecrotic activities.

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Year: 1983 PMID： 6315593 PMCID： PMC264423 DOI： 10.1128/iai.42.3.1183-1186.1983

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. Crystalline epsilon-prototoxin from Clostridium welchii.

Authors: R O THOMSON
Journal: Nature Date: 1962-01-06 Impact factor: 49.962

2. Clostridium welchii epsilon-toxin and antitoxin.

Authors: E S ORLANS; C B RICHARDS; V E JONES
Journal: Immunology Date: 1960-01 Impact factor: 7.397

3. The effect of Clostridium welchii type D culture filtrates on the permeability of the mouse intestine.

Authors: I BATTY; J J BULLEN
Journal: J Pathol Bacteriol Date: 1956-04

4. Structural studies on epsilon-prototoxin of Clostridium perfringens type D. Localization of the site of tryptic scission necessary for activation to epsilon-toxin.

Authors: A S Bhown; A F Habeerb
Journal: Biochem Biophys Res Commun Date: 1977-10-10 Impact factor: 3.575

5. Physical changes in the epsilon prototoxin molecule of Clostridium perfringens during enzymatic activation.

Authors: R W Worthington; M S Mülders
Journal: Infect Immun Date: 1977-11 Impact factor: 3.441

6. Studies on epsilon-prototoxin of Clostridium perfringens type D. I. Purification methods: evidence for multiple forms of epsilon-prototoxin.

Authors: A F Habeeb
Journal: Arch Biochem Biophys Date: 1969-03 Impact factor: 4.013

7. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors: K Weber; M Osborn
Journal: J Biol Chem Date: 1969-08-25 Impact factor: 5.157

8. Pharmacological effect of beta toxin of Clostridium perfringens type C on rats.

Authors: J Sakurai; Y Fujii; M Matsuura; K Endo
Journal: Microbiol Immunol Date: 1981 Impact factor: 1.955

9. Effect of carbohydrates and control of culture pH on beta toxin production by Clostridium perfringens type C.

Authors: J Sakurai; C L Duncan
Journal: Microbiol Immunol Date: 1979 Impact factor: 1.955

10. Studies on epsilon-prototoxin of Clostridium perfringens type D. Physicochemical and chemical properties of epsilon-prototoxin.

Authors: A F Habeeb
Journal: Biochim Biophys Acta Date: 1975-11-18

11 in total

1. High-affinity binding of Clostridium perfringens epsilon-toxin to rat brain.

Authors: M Nagahama; J Sakurai
Journal: Infect Immun Date: 1992-03 Impact factor: 3.441

2. Clostridium perfringens epsilon-toxin increases permeability of single perfused microvessels of rat mesentery.

Authors: R H Adamson; J C Ly; M Fernandez-Miyakawa; S Ochi; J Sakurai; F Uzal; F E Curry
Journal: Infect Immun Date: 2005-08 Impact factor: 3.441

3. Virulence plasmid diversity in Clostridium perfringens type D isolates.

Authors: Sameera Sayeed; Jihong Li; Bruce A McClane
Journal: Infect Immun Date: 2007-03-05 Impact factor: 3.441

Review 4. Role of pore-forming toxins in bacterial infectious diseases.

Authors: Ferdinand C O Los; Tara M Randis; Raffi V Aroian; Adam J Ratner
Journal: Microbiol Mol Biol Rev Date: 2013-06 Impact factor: 11.056

Review 5. Clostridial enteric diseases of domestic animals.

Authors: J G Songer
Journal: Clin Microbiol Rev Date: 1996-04 Impact factor: 26.132

6. Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex.

Authors: L Petit; M Gibert; D Gillet; C Laurent-Winter; P Boquet; M R Popoff
Journal: J Bacteriol Date: 1997-10 Impact factor: 3.490

7. Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model.

Authors: Sameera Sayeed; M E Fernandez-Miyakawa; Derek J Fisher; Vicki Adams; Rachael Poon; Julian I Rood; Francisco A Uzal; Bruce A McClane
Journal: Infect Immun Date: 2005-11 Impact factor: 3.441

8. Tryptophan content of Clostridium perfringens epsilon toxin.

Authors: J Sakurai; M Nagahama
Journal: Infect Immun Date: 1985-01 Impact factor: 3.441

9. Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin.

Authors: Susan L Robertson; Jihong Li; Francisco A Uzal; Bruce A McClane
Journal: PLoS One Date: 2011-07-11 Impact factor: 3.240

10. Recombinant expression of in silico identified Bcell epitope of epsilon toxin of Clostridium perfringens in translational fusion with a carrier protein.

Authors: Himani Kaushik; Sachin Deshmukh; Deepika Dayal Mathur; Archana Tiwari; Lalit C Garg
Journal: Bioinformation Date: 2013-07-12