Literature DB >> 6315475

Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?

I S Cohen.   

Abstract

It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.

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Year:  1983        PMID： 6315475     DOI： 10.1007/bf01990370

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Effects of strophanthidin upon contraction and ionic exchange in rabbit ventricular myocardium: relation to control of active state.

Authors:  G A Langer; S D Serena
Journal:  J Mol Cell Cardiol       Date:  1970-03       Impact factor: 5.000

2.  Electrogenic suppression of automaticity in sheep and dog purkinje fibers.

Authors:  M Vassalle
Journal:  Circ Res       Date:  1970-09       Impact factor: 17.367

3.  Potassium fluxes in voltage clamped Purkinje fibres.

Authors:  H G Haas; R Kern
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1966

4.  Importance of the lactone ring for the action of therapeutic doses of ouabain in guinea-pig atria [proceedings].

Authors:  J Ghysel-Burton; T Godfraind
Journal:  J Physiol       Date:  1977-03       Impact factor: 5.182

Review 5.  K+ fluctuations in the extracellular spaces of cardiac muscle. Evidence from the voltage clamp and extracellular K+ - selective microelectrodes.

Authors:  I Cohen; R Kline
Journal:  Circ Res       Date:  1982-01       Impact factor: 17.367

6.  Inhibition of myocardial monovalent cation active transport by subtoxic doses of ouabain in the dog.

Authors:  T J Hougen; T W Smith
Journal:  Circ Res       Date:  1978-06       Impact factor: 17.367

7.  The ouabain-sensitive fluxes of sodium and potassium in squid giant axons.

Authors:  P F Baker; M P Blaustein; R D Keynes; J Manil; T I Shaw; R A Steinhardt
Journal:  J Physiol       Date:  1969-02       Impact factor: 5.182

8.  Characterization of the electrogenic sodium pump in cardiac Purkinje fibres.

Authors:  D A Eisner; W J Lederer
Journal:  J Physiol       Date:  1980-06       Impact factor: 5.182

9.  The effects of rubidium ions and membrane potentials on the intracellular sodium activity of sheep Purkinje fibres.

Authors:  D A Eisner; W J Lederer; R D Vaughan-Jones
Journal:  J Physiol       Date:  1981-08       Impact factor: 5.182

10.  Electrogenic sodium extrusion in cardiac Purkinje fibers.

Authors:  D C Gadsby; P F Cranefield
Journal:  J Gen Physiol       Date:  1979-06       Impact factor: 4.086
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  3 in total

1.  Dissociation between force and intracellular sodium activity with strophanthidin in isolated sheep Purkinje fibres.

Authors:  M R Boyett; G Hart; A J Levi
Journal:  J Physiol       Date:  1986-12       Impact factor: 5.182

2.  Relation between Na+-K+ pump, Na+ activity and force in strophanthidin inotropy in sheep cardiac Purkinje fibres.

Authors:  P Abete; M Vassalle
Journal:  J Physiol       Date:  1988-10       Impact factor: 5.182

3.  Effects of stimulation and diphenylhydantoin on the intracellular sodium activity in Purkinje fibres of sheep heart.

Authors:  D Ellis
Journal:  J Physiol       Date:  1985-05       Impact factor: 5.182
  3 in total

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