Characteristics and regulation of angiotensin II receptors in pituitary, circumventricular organs and kidney.

Receptors for angiotensin II (AII) have been identified and characterized in many AII-responsive tissues. Those in the adrenal zona glomerulosa and vascular smooth muscle undergo dynamic regulation which appears to be mediated by changes in circulating AII, and is followed by parallel changes in sensitivity to AII. Pituitary AII receptors are mainly located in lactotrophs and corticotrophs, where they mediate specific actions of AII upon prolactin and ACTH secretion, acting in conjunction with other hypothalamic regulators. In contrast to adrenal and vascular AII receptors, those in the anterior pituitary are not affected by changes in salt balance or AII infusion. In the brain, AII receptors were increased in the subfornical organ during dehydration, but show no significant changes in the other circumventricular organs. The increase in subfornical organ receptors resembles the up-regulation of AII sites which occurs in the adrenal cortex during sodium deficiency, and could play a role in potentiating the dipsogenic effect of AII in dehydration. In the rat kidney, AII receptors have been localized in both cortex and medulla by autoradiography with 125I-[Sar1]AII. While the renal cortical receptors appear to be localized to glomeruli, the most striking feature of these studies is the abundance of specific, high-affinity AII receptors in the renal medulla.