Literature DB >> 6315176

Evidence for a GABAergic inhibitory influence on serotonergic neurons originating from the dorsal raphe.

T Nishikawa, B Scatton.   

Abstract

Systemic administration of progabide, dipropylacetamide and gamma-acetylenic-GABA diminished striatal 5-HTP accumulation; the effect of progabide was abolished after hemitransection. Intradorsal raphé (but not intrastriatal) infusion of GABA or GABA agonist agents reduced striatal 5-HTP accumulation. Infusion of picrotoxinin or bicuculline into the dorsal raphé was without effect. It is concluded that GABA exerts an inhibitory influence on striatal serotonergic transmission via stimulation of GABA receptors located in the dorsal raphé.

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Year:  1983        PMID： 6315176     DOI： 10.1016/0006-8993(83)90203-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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Review 3.  The organization and regulation of sleep. A review of the experimental evidence and a novel integrated model of the organizing and regulating apparatus.

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Authors:  T Dennis; O Curet; T Nishikawa; B Scatton
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8.  Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat.

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Journal:  Neurochem Res       Date:  1992-05       Impact factor: 3.996

9.  Effects of GABA-ergic drugs on penile erection induced by apomorphine in rats.

Authors:  M R Zarrindast; H Farahvash
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  9 in total

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