Literature DB >> 6315141

The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. II. Receptor binding.

L P Tuff, R J Racine, R K Mishra.   

Abstract

Receptor binding estimates of the number of GABA and associated benzodiazepine (Bz) receptors were made in several brain regions following kindling. While the number of GABA receptors, as measured by both [3H]GABA and [3H]muscimol binding, was unaltered by kindling, Bz receptors were significantly increased in kindled amygdala and hippocampus. As the Bz receptor apparently functions to enhance GABA transmission, this finding suggests a possible mechanism for the kindling-induced enhancement of inhibition observed in previous evoked potential experiments.

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Year:  1983        PMID： 6315141     DOI： 10.1016/0006-8993(83)90910-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

1.  Regional changes in gene expression after limbic kindling.

Authors:  M E Corcoran; R A Kroes; J S Burgdorf; J R Moskal
Journal:  Cell Mol Neurobiol       Date:  2011-03-19       Impact factor: 5.046

2.  The postsynaptic density: a possible role in long-lasting effects in the central nervous system.

Authors:  P Siekevitz
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

3.  Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats.

Authors:  Umit Sayin; Susan Osting; Joshua Hagen; Paul Rutecki; Thomas Sutula
Journal:  J Neurosci       Date:  2003-04-01       Impact factor: 6.167

4.  Inhibitory processes in development of seizure activity in hippocampal slices.

Authors:  M Higashima
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

Review 5.  A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures.

Authors:  R M Post; S R Weiss
Journal:  Mol Neurobiol       Date:  1996-08       Impact factor: 5.590

6.  Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents.

Authors:  T S Otis; Y De Koninck; I Mody
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

7.  Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.

Authors:  U Sayin; E Hutchinson; M E Meyerand; T Sutula
Journal:  Neuroscience       Date:  2014-12-30       Impact factor: 3.590

8.  Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation.

Authors:  S B Bausch; C Chavkin
Journal:  J Neurosci       Date:  1997-01-01       Impact factor: 6.167

9.  Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

Authors:  Maxime Lévesque; Pariya Salami; Charles Behr; Massimo Avoli
Journal:  Epilepsia       Date:  2012-11-28       Impact factor: 5.864

10.  Pharmacological and neurochemical aspects of kindling.

Authors:  M Schmutz; M Klein; K Klebs; R Bernasconi; H Bittiger; V Baltzer
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575
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