Literature DB >> 6315011

Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types.

P Vigne, C Frelin, E J Cragoe, M Lazdunski.   

Abstract

Ethylisopropyl-amiloride is 100 times more potent than amiloride for inhibiting the Na+/H+ exchanger of 3T3 fibroblasts, chick skeletal muscle cells and chick cardiac cells. Half-maximum effects, measured at 3 mM external Na+ are observed at 20-100 nM and 5 microM for ethylisopropyl-amiloride and amiloride respectively. As previously observed for amiloride, the effect of ethylisopropyl-amiloride is antagonized by external Na+ ions.

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Year:  1983        PMID： 6315011     DOI： 10.1016/0006-291x(83)90384-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  39 in total

1.  Characterization of basolateral Na/H exchange (Na/H-1) in MDCK cells.

Authors:  S Vilella; L Guerra; C Helmle-Kolb; H Murer
Journal:  Pflugers Arch       Date:  1992-03       Impact factor: 3.657

2.  Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp.

Authors:  Martin P Stewart; Yusuke Toyoda; Anthony A Hyman; Daniel J Müller
Journal:  Nat Protoc       Date:  2012-01-05       Impact factor: 13.491

3.  Na+ modulates carrier-mediated Fe2+ transport through the erythroid cell membrane.

Authors:  A Egyed
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

4.  Studies on the kinetics of Na+/H+ exchange in OK cells: introduction of a new device for the analysis of polarized transport in cultured epithelia.

Authors:  D Krayer-Pawlowska; C Helmle-Kolb; M H Montrose; R Krapf; H Murer
Journal:  J Membr Biol       Date:  1991-03       Impact factor: 1.843

5.  Polarized expression of Na+/H+ exchange activities in clonal LLC-PK1 cells (Clone4 and PKE20) I. Basic characterization.

Authors:  V Casavola; C Helmle-Kolb; M H Montrose; H Murer
Journal:  Pflugers Arch       Date:  1991-04       Impact factor: 3.657

6.  Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats.

Authors:  Xueren Zhao; Fredric A Gorin; Robert F Berman; Bruce G Lyeth
Journal:  J Neurotrauma       Date:  2008-10       Impact factor: 5.269

7.  Identification of the renal Na+/H+ exchanger with N,N'-dicyclohexylcarbodiimide (DCCD) and amiloride analogues.

Authors:  T Friedrich; J Sablotni; G Burckhardt
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

8.  The effect of amiloride on the resting potential and the electrical constants of frog skeletal muscle fibres.

Authors:  F Estrada; J A Sanchez
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

9.  Inhibition of neuronal noradrenaline transport (uptake1) and desipramine binding by amiloride and ethylisopropylamiloride.

Authors:  E Schömig; J Michael-Hepp; C L Schönfeld
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

10.  3,4 dichlorobenzamil-sensitive, monovalent cation channel induced by palytoxin in cultured aortic myocytes.

Authors:  C van Renterghem; C Frelin
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739
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