| Literature DB >> 6313199 |
F Sicuteri, A Panconesi, G Franchi, P L Del Bianco, B Anselmi.
Abstract
Tachyphylaxis (TPX) to the spasmogenic activity of 5HT can be demonstrated in vivo in the superficial hand dorsal veins in man by the computerized venotest. The 5HT-TPX is reverted by previous local naloxone administration. Tachyphylaxis to 5HT is usually absent in the migraineur. The restored 5HT spasmogenic effect by naloxone suggests the possibility of local opioid apparatus participation in TPX to 5HT.Entities:
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Year: 1983 PMID： 6313199 DOI： 10.1046/j.1468-2982.1983.0303139.x
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292