Literature DB >> 6313109

Leukotriene B4: biological activities and the cytoskeleton.

F M Cunningham, M J Smith.   

Abstract

The aggregation and chemokinesis of either rat or human polymorphonuclear leucocytes (PMNs) induced by leukotriene B4 isomer III (LTB4) are inhibited significantly by colchicine (10(-6) - 10(-3)M) and vinblastine (10(-7) - 10(-4)M). Random migration of the leucocytes is inhibited by colchicine 10(-3)M and vinblastine 10(-4)M. Cytochalasin B (4 X 10(-7) - 4 X 10(-6)M) caused the aggregation of rat PMNs but inhibited their random migration. The aggregation of the PMNs induced by LTB4 was enhanced by cytochalasin B but the chemokinesis was inhibited. It is suggested that both microtubules and microfilaments may be involved in the aggregatory and chemokinetic responses of PMNs to LTB4.

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Year:  1982        PMID： 6313109      PMCID： PMC2071614          DOI： 10.1111/j.1476-5381.1982.tb08798.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

Review 1.  Chemotactic factors and the neutrophil.

Authors:  J T O'Flaherty; P A Ward
Journal:  Semin Hematol       Date:  1979-04       Impact factor: 3.851

2.  Cytochalasin binding in lymphocytes and polymorphonuclear leukocytes.

Authors:  C W Parker; W C Greene; H H MacDonald
Journal:  Exp Cell Res       Date:  1976-11       Impact factor: 3.905

3.  Effect of cytochalasin B on human neutrophil aggregation.

Authors:  J T O'Flaherty; D L Kreutzer; P A Ward
Journal:  Exp Cell Res       Date:  1979-04       Impact factor: 3.905

4.  Aggregation of rat polymorphonuclear leucocytes in vitro.

Authors:  F M Cunningham; M E Shipley; M J Smith
Journal:  J Pharm Pharmacol       Date:  1980-05       Impact factor: 3.765

5.  Desensitization of the neutrophil aggregation response to chemotactic factors.

Authors:  J T O'Flaherty; D L Kreutzer; H S Showell; E L Becker; P A Ward
Journal:  Am J Pathol       Date:  1978-12       Impact factor: 4.307

6.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

7.  The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leucocyte chemokinesis.

Authors:  M J Smith; J R Walker
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

8.  Inverse correlation between neutrophil microtubule numbers and enhanced random migration.

Authors:  A M Rich; S T Hoffstein
Journal:  J Cell Sci       Date:  1981-04       Impact factor: 5.285

9.  Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis.

Authors:  H L Malech; R K Root; J I Gallin
Journal:  J Cell Biol       Date:  1977-12       Impact factor: 10.539

10.  Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B.

Authors:  J H Hartwig; T P Stossel
Journal:  J Cell Biol       Date:  1976-10       Impact factor: 10.539
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  2 in total

1. 

Authors:  R Rochels
Journal:  Doc Ophthalmol       Date:  1984-05       Impact factor: 2.379

2.  Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin.

Authors:  P G Hellewell; H Yarwood; T J Williams
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739
  2 in total

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