Literature DB >> 6313054

Involvement of microtubules in the isoproterenol-induced 'down'-regulation of myocardial beta-adrenergic receptors.

C J Limas, C Limas.   

Abstract

The number of cardiac beta-adrenergic receptors identified by [3H]dihydroalprenolol binding decreases in a concentration-dependent manner during prolonged administration of isoproterenol. Loss of membrane beta-receptors is paralleled by the appearance of [3H]dihydroalprenolol binding activity in the cytosol. This redistribution of receptors is prevented by colchicine and vinblastine but not lumicolchicine. Cardiac receptor desensitization is, therefore, dependent on microtubules and may be influenced by agents interfering with tubulin polymerization.

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Year:  1983        PMID： 6313054     DOI： 10.1016/0005-2736(83)90273-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Sar1 translocation onto the ER-membrane for vesicle budding has different pathways for promotion and suppression of ER-to-Golgi transport mediated through H89-sensitive kinase and ER-resident G protein.

Authors:  Hiroshi Nakagawa; Masakazu Ishizaki; Shuichi Miyazaki; Takuto Abe; Kazuhiko Nishimura; Masayuki Komori; Saburo Matsuo
Journal:  Mol Cell Biochem       Date:  2012-04-07       Impact factor: 3.396

Review 2.  Mechanical modulation of cardiac microtubules.

Authors:  Ed White
Journal:  Pflugers Arch       Date:  2011-04-13       Impact factor: 3.657

Review 3.  Cardiac microtubules in health and heart disease.

Authors:  Matthew A Caporizzo; Christina Yingxian Chen; Benjamin L Prosser
Journal:  Exp Biol Med (Maywood)       Date:  2019-08-09

4.  Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing.

Authors:  Nazira Özgen; Zhongju Lu; Gerard J J Boink; David H Lau; Iryna N Shlapakova; Yevgeniy Bobkov; Peter Danilo; Ira S Cohen; Michael R Rosen
Journal:  Heart Rhythm       Date:  2012-07-20       Impact factor: 6.343

Review 5.  Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation.

Authors:  D R Sibley; R J Lefkowitz
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

6.  Concanavalin A amplifies both beta-adrenergic and muscarinic cholinergic receptor-adenylate cyclase-linked pathways in cardiac myocytes.

Authors:  K J Rocha-Singh; D K Hines; N Y Honbo; J S Karliner
Journal:  J Clin Invest       Date:  1991-09       Impact factor: 14.808
  6 in total

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