Literature DB >> 6313029

Ranitidine does not affect gonadal function in man.

C Wang, K L Wong, K C Lam, C L Lai.   

Abstract

We studied the effect of ranitidine on gonadal function in 20 male subjects with chronic duodenal ulcer. Eleven were treated with ranitidine 150 mg twice daily for 3 months and 150 mg at night for 9 months, nine with placebo for 3 months. Similar to placebo, treatment with ranitidine did not influence basal serum concentrations of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL). No significant changes were found in sperm concentration, motility or morphology. Ranitidine does not affect gonadal function in man.

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Year:  1983        PMID： 6313029      PMCID： PMC1428021          DOI： 10.1111/j.1365-2125.1983.tb02190.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  6 in total

1.  Effect of cimetidine on gonadal function in man.

Authors:  C Wang; C L Lai; K C Lam; K K Yeung
Journal:  Br J Clin Pharmacol       Date:  1982-06       Impact factor: 4.335

2.  Analysis of human spermatozoal fertilizing ability using zona-free ova.

Authors:  B J Rogers; H Van Campen; M Ueno; H Lambert; R Bronson; R Hale
Journal:  Fertil Steril       Date:  1979-12       Impact factor: 7.329

3.  Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17 beta during treatment of duodenal ulcer in male patients.

Authors:  N R Peden; E J Boyd; M C Browning; J H Saunders; K G Wormsley
Journal:  Acta Endocrinol (Copenh)       Date:  1981-04

4.  Cimetidine is an antiandrogen in the rat.

Authors:  S J Winters; J L Banks; D L Loriaux
Journal:  Gastroenterology       Date:  1979-03       Impact factor: 22.682

5.  Cimetidine, a histamine H2 receptor antagonist, occupies androgen receptors.

Authors:  J W Funder; J E Mercer
Journal:  J Clin Endocrinol Metab       Date:  1979-02       Impact factor: 5.958

6.  Hypothalamic-pituitary-gonadal dysfunction in men using cimetidine.

Authors:  D H Van Thiel; J S Gavaler; W I Smith; G Paul
Journal:  N Engl J Med       Date:  1979-05-03       Impact factor: 91.245
  6 in total
  6 in total

Review 1.  Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  H D Langtry; S M Grant; K L Goa
Journal:  Drugs       Date:  1989-10       Impact factor: 9.546

Review 2.  Safety of acid-suppressing drugs.

Authors:  R A Smallwood; R G Berlin; N Castagnoli; H P Festen; C J Hawkey; S K Lam; M J Langman; P Lundborg; A Parkinson
Journal:  Dig Dis Sci       Date:  1995-02       Impact factor: 3.199

Review 3.  Side effects of ranitidine.

Authors:  T Vial; C Goubier; A Bergeret; F Cabrera; J C Evreux; J Descotes
Journal:  Drug Saf       Date:  1991 Mar-Apr       Impact factor: 5.606

Review 4.  Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  S M Grant; H D Langtry; R N Brogden
Journal:  Drugs       Date:  1989-06       Impact factor: 9.546

Review 5.  Adverse reactions and interactions with H2-receptor antagonists.

Authors:  J Penston; K G Wormsley
Journal:  Med Toxicol       Date:  1986 May-Jun

6.  Effect of Medications for Gastric Acid-Related Symptoms on Total Motile Sperm Count and Concentration: A Case-Control Study in Men of Subfertile Couples from the Netherlands.

Authors:  Nicole A Huijgen; Hedwig J Goijen; John M Twigt; Annemarie G M G J Mulders; Jan Lindemans; Gert R Dohle; Joop S E Laven; Régine P M Steegers-Theunissen
Journal:  Drug Saf       Date:  2017-03       Impact factor: 5.606
  6 in total

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