Literature DB >> 6312969

Stimulatory effect of the intestinal peptide PHI on glycogenolysis and gluconeogenesis in isolated rat hepatocytes.

J E Felíu, J Marco.   

Abstract

The newly isolated peptide PHI provoked a dose-dependent stimulation of glycogenolysis and gluconeogenesis in isolated rat hepatocytes; at 1 microM-PHI, both processes were increased 1.6-fold as compared with basal values. These PHI-mediated effects were accompanied by the activation of glycogen phosphorylase and the inactivation of pyruvate kinase. PHI (1 microM) also caused a 2-fold increase in hepatocyte cyclic AMP.

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Year:  1983        PMID： 6312969      PMCID： PMC1152344          DOI： 10.1042/bj2140999

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  The interaction of vasoactive intestinal polypeptide and secretin with liver-cell membranes.

Authors:  B Desbuquois
Journal:  Eur J Biochem       Date:  1974-08-01

2.  Actions of a newly isolated intestinal peptide PHI on pancreatic acini.

Authors:  R T Jensen; K Tatemoto; V Mutt; G F Lemp; J D Gardner
Journal:  Am J Physiol       Date:  1981-12

3.  Actions of a new peptide from porcine intestine (PHI) on pancreatic secretion in the rat and turkey.

Authors:  R Dimaline; G J Dockray
Journal:  Life Sci       Date:  1980-11-24       Impact factor: 5.037

4.  Porcine peptide having N-terminal histidine and C-terminal isoleucine amide (PHI): vasoactive intestinal peptide (VIP) and secretin-like effects in different tissues from the rat.

Authors:  D Bataille; C Gespach; M Laburthe; B Amiranoff; K Tatemoto; N Vauclin; V Mutt; G Rosselin
Journal:  FEBS Lett       Date:  1980-06-02       Impact factor: 4.124

5.  Interaction of a newly isolated intestinal polypeptide (PHI) with glucose and arginine to effect the secretion of insulin and glucagon.

Authors:  J Szecówka; K Tatemoto; V Mutt; S Efendić
Journal:  Life Sci       Date:  1980-02-11       Impact factor: 5.037

6.  Control of gluconeogenesis and of enzymes of glycogen metabolism in isolated rat hepatocytes. A parallel study of the effect of phenylephrine and of glucagon.

Authors:  L Hue; J E Felíu; H G Hers
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

Review 7.  The control of glycogen metabolism in the liver.

Authors:  H G Hers
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

8.  Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.

Authors:  J E Feliú; L Hue; H G Hers
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

9.  Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family.

Authors:  K Tatemoto; V Mutt
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

10.  Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides.

Authors:  K Tatemoto; V Mutt
Journal:  Nature       Date:  1980-06-05       Impact factor: 49.962
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  1 in total

1.  Physiological changes and gastro-intestinal symptoms as a result of ultra-endurance running.

Authors:  N J Rehrer; F Brouns; E J Beckers; W O Frey; B Villiger; C J Riddoch; P P Menheere; W H Saris
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1992
  1 in total

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