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Literature DB >> 631275

Is the effect of diphenolic laxatives mediated via release of prostaglandin E?

Abstract

The diphenolic laxatives, bisacodyl and phenolphthalein, and the osmotic laxative mannitol increase intestinal fluid volume in the rat colon in situ. The diphenolic laxatives stimulate the biosynthesis of prostaglandin E (PGE) whereas mannitol does not. Inhibition of PG-biosynthesis by pretreatment with indomethacin only reduces the effect of the diphenolic laxatives. It is suggested that diphenolic laxatives increase intestinal fluid volume via stimulation of PGE biosynthesis in the colon.

Entities: Chemical Species

Mesh：

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Year: 1978 PMID： 631275 DOI： 10.1007/bf01923051

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

11 in total

1. The function of prostaglandins in transmucosal water movement and blood flow in the rat jejunum.

Authors: E Beubler; H Juan
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-08 Impact factor: 3.000

2. Release of prostaglandins from isolated cat spleen by angiotensin and vasopressin.

Authors: B Peskar; G Hertting
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

3. Influx and efflux of sodium in jejunal and colonic segments of rats under the influence of oxyphenisatin.

Authors: G Nell; H Overhoff; W Forth; H Kulenkampff; W Specht; W Rummel
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

4. Effect of prostaglandin E 1 on glucose, water, and electrolyte absorption in the human jejunum.

Authors: C Matuchansky; J J Bernier
Journal: Gastroenterology Date: 1973-06 Impact factor: 22.682

5. Aspirin selectively inhibits prostaglandin production in human platelets.

Authors: J B Smith; A L Willis
Journal: Nat New Biol Date: 1971-06-23

6. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

7. Indomethacin and aspirin abolish prostaglandin release from the spleen.

Authors: S H Ferreira; S Moncada; J R Vane
Journal: Nat New Biol Date: 1971-06-23

8. Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum.

Authors: N F Pierce; C C Carpenter; H L Elliott; W B Greenough
Journal: Gastroenterology Date: 1971-01 Impact factor: 22.682

5. Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine.

Authors: D Rachmilewitz; F Karmeli; E Okon
Journal: Dig Dis Sci Date: 1980-08 Impact factor: 3.199

6. Are prostaglandins cytoprotective in the human large intestine? The effect of indomethacin on rectal mucosal function and prostaglandin E2 release in vivo.

Authors: D S Rampton; T P Barton
Journal: Agents Actions Date: 1984-06

7. Inhibition by morphine of prostaglandin E1-stimulated secretion and cyclic adenosine 3',5'-monophosphate formation in the rat jejunum in vivo.

Authors: E Beubler; F Lembeck
Journal: Br J Pharmacol Date: 1980-03 Impact factor: 8.739

7 in total

Is the effect of diphenolic laxatives mediated via release of prostaglandin E?

1. The function of prostaglandins in transmucosal water movement and blood flow in the rat jejunum.

2. Release of prostaglandins from isolated cat spleen by angiotensin and vasopressin.

3. Influx and efflux of sodium in jejunal and colonic segments of rats under the influence of oxyphenisatin.

4. Effect of prostaglandin E 1 on glucose, water, and electrolyte absorption in the human jejunum.

5. Aspirin selectively inhibits prostaglandin production in human platelets.

6. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

7. Indomethacin and aspirin abolish prostaglandin release from the spleen.

8. Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum.

Review 9. Some aspects of the pharmacology of anthraquinone drugs.

10. ANTIBODIES TO BRADYKININ AND ANGIOTENSIN: A USE OF CARBODIIMIDES IN IMMUNOLOGY.

1. Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists.

Review 2. Prostaglandins and ulcerative colitis.

3. PGE-mediated laxative effect of diphenolic laxatives.

4. A prostaglandin-like activity in small intestine and postirradiation gastrointestional syndrome.

5. Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine.

6. Are prostaglandins cytoprotective in the human large intestine? The effect of indomethacin on rectal mucosal function and prostaglandin E2 release in vivo.

7. Inhibition by morphine of prostaglandin E1-stimulated secretion and cyclic adenosine 3',5'-monophosphate formation in the rat jejunum in vivo.