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Literature DB >> 6312406

The effect of kininase II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin.

Abstract

Bradykinin (BK) produced concentration-related relaxations of cat middle cerebral arteries and was ineffective on cat basilar arteries in vitro under resting tension and when contracted with 5-hydroxy-tryptamine (5-HT). Angiotensin I and II (AI, AII) produced concentration-related contraction on both arteries, AII being approximately 10 times more potent than AI. The angiotensin-converting-enzyme inhibitors, SQ, 14225, BPP5a and BPP9a had no effect on the concentration effect curves to BK, AII or 5-HT but responses to AI were inhibited. These results suggest that angiotensin-converting-enzyme is present in both preparations and is important for the conversion of AI to AII but apparently not for the degradation of BK.

Entities: Chemical Disease Gene

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Year: 1983 PMID： 6312406 DOI： 10.1007/bf00581069

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

8 in total

1. An enzyme in human blood plasma that inactivates bradykinin and kallidins.

Authors: E G ERDOS; E M SLOANE
Journal: Biochem Pharmacol Date: 1962-07 Impact factor: 5.858

2. Kininases and vascular responses to kinins.

Authors: C Babiuk; F Marceau; S St-Pierre; D Regoli
Journal: Eur J Pharmacol Date: 1982-02-26 Impact factor: 4.432

3. Effects of kininase II inhibitors on the vasomotor response to bradykinin of feline intracranial and extracranial arteries in vitro and in situ.

Authors: M Wahl; A R Young; L Edvinsson; F Wagner
Journal: J Cereb Blood Flow Metab Date: 1983-09 Impact factor: 6.200

Review 4. Pharmacology of bradykinin and related kinins.

Authors: D Regoli; J Barabé
Journal: Pharmacol Rev Date: 1980-03 Impact factor: 25.468

5. Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence.

Authors: U S Ryan; J W Ryan; C Whitaker; A Chiu
Journal: Tissue Cell Date: 1976 Impact factor: 2.466

6. Angiotensin-converting enzyme: vascular endothelial localization.

Authors: P R Caldwell; B C Seegal; K C Hsu; M Das; R L Soffer
Journal: Science Date: 1976-03-12 Impact factor: 47.728

7. Effects of bradykinin on pial arteries and arterioles in vitro and in situ.

Authors: M Wahl; A R Young; L Edvinsson; F Wagner
Journal: J Cereb Blood Flow Metab Date: 1983-06 Impact factor: 6.200

8. Actions of bradykinin on isolated cerebral and peripheral arteries.

Authors: N Toda
Journal: Am J Physiol Date: 1977-03

8 in total

4 in total

The effect of kininase II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin.

1. An enzyme in human blood plasma that inactivates bradykinin and kallidins.

2. Kininases and vascular responses to kinins.

3. Effects of kininase II inhibitors on the vasomotor response to bradykinin of feline intracranial and extracranial arteries in vitro and in situ.

Review 4. Pharmacology of bradykinin and related kinins.

5. Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence.

6. Angiotensin-converting enzyme: vascular endothelial localization.

7. Effects of bradykinin on pial arteries and arterioles in vitro and in situ.

8. Actions of bradykinin on isolated cerebral and peripheral arteries.

1. Demonstration of extrapulmonary activity of angiotensin converting enzyme in intact tissue preparations.

2. The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice.

3. Kinin receptors and angiotensin converting enzyme in rabbits basilar arteries.

Review 4. Angiotensin converting enzyme inhibition and cerebral circulation--a review.