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Literature DB >> 6312349

Differential effects of some transition metal cations on the binding of beta-carboline-3-carboxylate and diazepam.

Abstract

The interaction of benzodiazepines and beta-carbolines with metal cations was investigated. Among numerous transition metal cations, only three, CO2+, Ni2+ and Zn2+, specifically inhibited the binding of [3H]beta-carboline-3-carboxylate ethyl ester (beta-CCE). The effects of these cations on [3H]beta-CCE binding were exactly opposite to those on [3H]diazepam binding. The effects of these cations was not dependent on lipid peroxidation. The differential effect of these cations may reflect a general difference in the way agonists and antagonists bind to the benzodiazepine receptor.

Entities: Chemical

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Year: 1983 PMID： 6312349 DOI： 10.1007/bf00964548

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

16 in total

5. Thermodynamic changes associated with benzodiazepine and alkyl beta-carboline-3-carboxylate binding to rat brain homogenates.

Authors: R L Kochman; J D Hirsch
Journal: Mol Pharmacol Date: 1982-09 Impact factor: 4.436

Differential effects of some transition metal cations on the binding of beta-carboline-3-carboxylate and diazepam.

1. Biochemical identification of the site of action of benzodiazepines in human brain by 3H-diazepam binding.

2. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

3. The proconvulsant and diazepam-reversing effects of ethyl-beta-carboline-3-carboxylate.

4. GABA reduces binding of 3H-methyl beta-carboline-3-carboxylate to brain benzodiazepine receptors.

5. Thermodynamic changes associated with benzodiazepine and alkyl beta-carboline-3-carboxylate binding to rat brain homogenates.

6. Effects of cations and anions on the binding of 3H-diazepam to rat brain.

7. Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

8. beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity.

9. Ethyl beta-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats.

10. Super-high-affinity binding site for [3H]diazepam in the presence of Co2+, Ni2+, Cu2+, or Zn2+.

1. Effect of ferric nitrilotriacetate on rostral mesencephalic cells.

2. Lack of specificity in cation effects on solubilized benzodiazepine receptor.