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Literature DB >> 6312088

Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus.

S J O'Brien, E J Berman, J D Estes, M B Gardner.

Abstract

The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4R) X LCRR (Akvr-1R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1R and Fv-4R are alleles of a single locus, Fv-4, on mouse chromosome 12.

Entities: Gene Species

Mesh：

Year: 1983 PMID： 6312088 PMCID： PMC255307

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

15 in total

1. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice.

Authors: F Lilly
Journal: J Natl Cancer Inst Date: 1970-07 Impact factor: 13.506

2. Genetic resistance in Japanese wild mice (Mus musculus molossinus) to an NB-tropic Friend murine leukemia virus.

Authors: T Odaka; H Ikeda; K Moriwaki; A Matsuzawa; M Mizuno; K Kondo
Journal: J Natl Cancer Inst Date: 1978-11 Impact factor: 13.506

3. FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus.

Authors: S Suzuki
Journal: Jpn J Exp Med Date: 1975-12

4. Isolation of Friend leukemia virus resistant line from non-inbred mouse colony.

Authors: S Suzuki; S Matsubara
Journal: Jpn J Exp Med Date: 1975-12

5. Unstable resistance of G mouse fibroblasts to ecotropic murine leukemia virus infection.

Authors: H Yoshikura; Y Naito; K Moriwaki
Journal: J Virol Date: 1979-03 Impact factor: 5.103

6. Restricted expression of endogenous N-tropic XC-positive leukemia virus in hybrids between G and AKR mice: an effect of the Fv-4r gene.

Authors: T Odaka; H Ikeda; T Akatsuka
Journal: Int J Cancer Date: 1980-06-15 Impact factor: 7.396

7. Resistance of G mice to murine leukemia virus infection: apparent disparity in in vivo and in vitro resistances.

Authors: H Yoshikura; T Odaka
Journal: J Natl Cancer Inst Date: 1978-08 Impact factor: 13.506

8. Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.

Authors: K Kai; H Ikeda; Y Yuasa; S Suzuki; T Odaka
Journal: J Virol Date: 1976-11 Impact factor: 5.103

9. Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

Authors: D Meruelo; M Leiberman; N Ginzton; B Deak; H O McDevitt
Journal: J Exp Med Date: 1977-10-01 Impact factor: 14.307

10. A major genetic locus affecting resistance to infection with murine leukemia viruses. 3. Assignment of the Fv-1 locus to linkage group 8 of the mouse.

Authors: W P Rowe; J B Humphrey; F Lilly
Journal: J Exp Med Date: 1973-03-01 Impact factor: 14.307

11 in total

Review 1. Mouse chromosome 12.

Authors: P D'Eustachio
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. Acquisition of two endogenous ecotropic murine leukemia viruses in distinct Asian wild mouse populations.

Authors: Y Inaguma; N Miyashita; K Moriwaki; W C Huai; M L Jin; X Q He; H Ikeda
Journal: J Virol Date: 1991-04 Impact factor: 5.103

3. Molecular characterization of the Akvr-1 restriction gene: a defective endogenous retrovirus-borne gene identical to Fv-4r.

Authors: S Dandekar; P Rossitto; S Pickett; G Mockli; H Bradshaw; R Cardiff; M Gardner
Journal: J Virol Date: 1987-02 Impact factor: 5.103

Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus.

1. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice.

2. Genetic resistance in Japanese wild mice (Mus musculus molossinus) to an NB-tropic Friend murine leukemia virus.

3. FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus.

4. Isolation of Friend leukemia virus resistant line from non-inbred mouse colony.

5. Unstable resistance of G mouse fibroblasts to ecotropic murine leukemia virus infection.

6. Restricted expression of endogenous N-tropic XC-positive leukemia virus in hybrids between G and AKR mice: an effect of the Fv-4r gene.

7. Resistance of G mice to murine leukemia virus infection: apparent disparity in in vivo and in vitro resistances.

8. Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.

9. Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

10. A major genetic locus affecting resistance to infection with murine leukemia viruses. 3. Assignment of the Fv-1 locus to linkage group 8 of the mouse.

Review 1. Mouse chromosome 12.

2. Acquisition of two endogenous ecotropic murine leukemia viruses in distinct Asian wild mouse populations.

3. Molecular characterization of the Akvr-1 restriction gene: a defective endogenous retrovirus-borne gene identical to Fv-4r.

4. Diverse wild mouse origins of xenotropic, mink cell focus-forming, and two types of ecotropic proviral genes.

5. Fv-4 resistance gene: a truncated endogenous murine leukemia virus with ecotropic interference properties.

6. A unique sequence related to the ecotropic murine leukemia virus is associated with the Fv-4 resistance gene.

Review 7. Genetic control of retroviral disease in aging wild mice.

8. Characterization of a molecularly cloned retroviral sequence associated with Fv-4 resistance.

9. Transgenic Fv-4 mice resistant to Friend virus.

10. Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling.