Literature DB >> 6311214

Phospholipase A2 modulation by calmodulin, prostaglandins and cyclic nucleotides.

N Moskowitz, L Shapiro, W Schook, S Puszkin.   

Abstract

Phospholipase A2 in the presence of Ca2+ was stimulated by calmodulin and by prostaglandin F2 alpha. Prostaglandin E2, cyclic-AMP and cyclic-GMP inhibited phospholipase A2 in the presence or absence of calmodulin. Dimethylsuberimidate cross-linking of phospholipase A2 with calmodulin was found to be Ca2+ dependent. These results indicate that phospholipase A2 is directly regulated by a host of key intracellular regulators and is one of the calmodulin-regulated enzymes.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6311214     DOI： 10.1016/0006-291x(83)90973-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin.

Authors:  N Suttorp; W Seeger; J Zucker-Reimann; L Roka; S Bhakdi
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441

2.  The effect of calcium channel blockers and calmodulin inhibitors on the macrophage factor-stimulated synthesis of collagenase by rabbit chondrocytes.

Authors:  J C Nolan; C E Gathright; L E Wagner
Journal:  Agents Actions       Date:  1988-08

3.  The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes.

Authors:  D A Halliday; J D McNeil; W H Betts; R Scicchitano
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

4.  Roles of Ca2+ and protein kinase C in regulation of prostaglandin E2 release by cultured rabbit gastric epithelial cells.

Authors:  S Ota; Y Hata; A Terano; K Yoshiura; H Hiraishi; T Kawabe; H Mutoh; S Shiina; T Sugimoto
Journal:  Dig Dis Sci       Date:  1993-08       Impact factor: 3.199

5.  Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

Authors:  J V Bonventre; M Swidler
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.