Literature DB >> 6311177

Stimulation of prostaglandin production through purinoceptors on cultured porcine endothelial cells.

J D Pearson, L L Slakey, J L Gordon.   

Abstract

ATP (approx. 1-300 microM) induces dose-dependent prostacyclin secretion from perfused columns of microcarrier beads with cultured endothelial monolayers attached. The response is transient, shows little tachyphylaxis and can reach approx. 100 times control values. 2-Methylthio-ATP is more potent, ADP slightly less potent, AMP much less potent and adenosine is ineffective. These results are consistent with the presence of a purinoceptor on endothelium linked to the prostacyclin synthetic pathway.

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Year:  1983        PMID： 6311177      PMCID： PMC1152238          DOI： 10.1042/bj2140273

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  Stimulation of prostaglandin biosynthesis by adenine nucleotides. Profile of prostaglandin release by perfused organs.

Authors:  P Needleman; M S Minkes; J R Douglas
Journal:  Circ Res       Date:  1974-04       Impact factor: 17.367

2.  Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture.

Authors:  J D Pearson; J S Carleton; J L Gordon
Journal:  Biochem J       Date:  1980-08-15       Impact factor: 3.857

3.  Microcarrier culture of vascular endothelial cells on solid plastic beads.

Authors:  P F Davies
Journal:  Exp Cell Res       Date:  1981-08       Impact factor: 3.905

4.  Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium.

Authors:  C Busch; W G Owen
Journal:  J Clin Invest       Date:  1982-03       Impact factor: 14.808

5.  Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

Authors:  J G De Mey; P M Vanhoutte
Journal:  J Physiol       Date:  1981-07       Impact factor: 5.182

6.  Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides.

Authors:  J D Pearson; J L Gordon
Journal:  Nature       Date:  1979-10-04       Impact factor: 49.962

7.  Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187.

Authors:  B B Weksler; C W Ley; E A Jaffe
Journal:  J Clin Invest       Date:  1978-11       Impact factor: 14.808

8.  Prostacyclin is not a circulating hormone in man.

Authors:  I A Blair; S E Barrow; K A Waddell; P J Lewis; C T Dollery
Journal:  Prostaglandins       Date:  1982-04

9.  Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells.

Authors:  A Ager; J L Gordon; S Moncada; J D Pearson; J A Salmon; M A Trevethick
Journal:  J Cell Physiol       Date:  1982-01       Impact factor: 6.384

10.  Uptake and metabolism of adenosine by pig aortic endothelial and smooth-muscle cells in culture.

Authors:  J D Pearson; J S Carleton; A Hutchings; J L Gordon
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857
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  47 in total

1.  Independent pathways regulate the cytosolic [Ca2+] initial transient and subsequent oscillations in individual cultured arterial smooth muscle cells responding to extracellular ATP.

Authors:  M G Mahoney; C J Randall; J J Linderman; D J Gross; L L Slakey
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

2.  Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium.

Authors:  S J Mason; A M Paradiso; R C Boucher
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

3.  Effects of pyrimidines on the guinea-pig coronary vasculature.

Authors:  A J Vials; G Burnstock
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

4.  Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells.

Authors:  D S Cowen; H M Lazarus; S B Shurin; S E Stoll; G R Dubyak
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

5.  Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.

Authors:  T M McIntyre; G A Zimmerman; K Satoh; S M Prescott
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

6.  Effects of amiloride analogues on the production of prostacyclin by aortic endothelial cells.

Authors:  J M Boeynaems; D Demolle; C Lagneau; E J Cragoe
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

7.  Effects of changes in extra- and intracellular K+ on the endothelial production of prostacyclin.

Authors:  J M Boeynaems; I Ramboer
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

8.  Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents.

Authors:  E C LeRoy; A Ager; J L Gordon
Journal:  J Clin Invest       Date:  1984-09       Impact factor: 14.808

9.  Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow.

Authors:  J Shen; M A Gimbrone; F W Luscinskas; C F Dewey
Journal:  Biophys J       Date:  1993-04       Impact factor: 4.033

10.  Evidence for a nucleotide receptor on adrenal medullary endothelial cells linked to phospholipase C and phospholipase D.

Authors:  J R Purkiss; G F Wilkinson; M R Boarder
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739
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