Some characteristics of the isolated ADP/ATP carrier.

The primary structure of the ADP/ATP carrier, comprising 297 amino acids, is discussed. Other structural features include the conformational changes related to the translocational process. Fluorescent adenine nucleotide analogs, DAN-AMP, DAN-ADP and DAN-ATP are being used for probing the transition between the "c" and "m" states. The fluorescent properties of the binding give strong support to the gated pore model, with "opposite" binding interfaces between substrate and carrier.