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Literature DB >> 6310587

One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain.

Abstract

A gene fusion between an Epstein-Barr virus (EBV) triplet nucleotide repeat array (IR3), which has homology to host DNA, and lacZ was used to demonstrate that this EBV sequence encodes part of the Epstein-Barr nuclear antigen (EBNA). The IR3 sequence is translated into a glycine-alanine copolymer that reacts with anti-EBNA human sera. Some EBV-immune human antisera recognize a second intranuclear protein that is also specific for latently infected cells and is designated EBNA2. EBNA2 is not related to EBNA1 because the molecular mass of EBNA2 is 82 kilodaltons, whereas that of EBNA1 varies from 68 to 85 kilodaltons among cells transformed by different EBV isolates; also EBNA2 does not contain the copolymer domain of EBNA1.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6310587 PMCID： PMC384319 DOI： 10.1073/pnas.80.18.5665

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

35 in total

1. PURIFICATION, COMPOSITION, AND MOLECULAR WEIGHT OF THE BETA-GALACTOSIDASE OF ESCHERICHIA COLI K12.

Authors: G R CRAVEN; E STEERS; C B ANFINSEN
Journal: J Biol Chem Date: 1965-06 Impact factor: 5.157

2. Isolation and characterization of the protein coded by gene A of bacteriophage phiX174 DNA.

Authors: J E Ikeda; A Yudelevich; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

3. Characterization of Epstein-Barr virus antigens. I. Biochemical analysis of the complement-fixing soluble antigen and relationship with Epstein-Barr virus-associated nuclear antigen.

Authors: G Lenoir; M C Berthelon; M C Favre; G de-Thé
Journal: J Virol Date: 1976-02 Impact factor: 5.103

4. Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells.

Authors: H Zur Hausen; H Schulte-Holthausen
Journal: Nature Date: 1970-07-18 Impact factor: 49.962

5. Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsies.

Authors: B M Reedman; G Klein; J H Pope; M K Walters; J Hilgers; S Singh; B Johansson
Journal: Int J Cancer Date: 1974-06-15 Impact factor: 7.396

6. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors: B M Reedman; G Klein
Journal: Int J Cancer Date: 1973-05 Impact factor: 7.396

7. Transformation of foetal human keukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus.

Authors: J H Pope; M K Horne; W Scott
Journal: Int J Cancer Date: 1968-11-15 Impact factor: 7.396

8. Reassociation kinetics for Epstein-Barr virus DNA: nonhomology to mammalian DNA and homology of viral DNA in various diseases.

Authors: Y Kawai; M Nonoyama; J S Pagano
Journal: J Virol Date: 1973-11 Impact factor: 5.103

9. Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx.

Authors: G Klein; B C Giovanella; T Lindahl; P J Fialkow; S Singh; J S Stehlin
Journal: Proc Natl Acad Sci U S A Date: 1974-12 Impact factor: 11.205

10. Antigens and DNA of a chimpanzee agent related to Epstein-Barr virus.

Authors: P Gerber; R F Pritchett; E D Kieff
Journal: J Virol Date: 1976-09 Impact factor: 5.103

88 in total

1. Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein-Barr virus type I latency.

Authors: M G Davenport; J S Pagano
Journal: J Virol Date: 1999-04 Impact factor: 5.103

2. BamHI E region of the Epstein-Barr virus genome encodes three transformation-associated nuclear proteins.

Authors: A Ricksten; B Kallin; H Alexander; J Dillner; R Fåhraeus; G Klein; R Lerner; L Rymo
Journal: Proc Natl Acad Sci U S A Date: 1988-02 Impact factor: 11.205

3. Epstein-Barr virus nuclear antigen 1 linear epitopes that are reactive with immunoglobulin A (IgA) or IgG in sera from nasopharyngeal carcinoma patients or from healthy donors.

Authors: H M Cheng; Y T Foong; C K Sam; U Prasad; J Dillner
Journal: J Clin Microbiol Date: 1991-10 Impact factor: 5.948

4. cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis.

Authors: Wei Yue; Julia Shackelford; Joseph S Pagano
Journal: J Virol Date: 2006-02 Impact factor: 5.103

5. Interaction of Epstein-Barr virus nuclear antigen 1 with the viral latent origin of replication.

Authors: J Hearing; Y Mülhaupt; S Harper
Journal: J Virol Date: 1992-02 Impact factor: 5.103

6. Expression of the Epstein-Barr virus nuclear protein 2 in rodent cells.

Authors: T Dambaugh; F Wang; K Hennessy; E Woodland; A Rickinson; E Kieff
Journal: J Virol Date: 1986-08 Impact factor: 5.103

7. Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins.

Authors: B Bühler; G M Keil; F Weiland; U H Koszinowski
Journal: J Virol Date: 1990-05 Impact factor: 5.103

8. In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein.

Authors: P M Lieberman; A J Berk
Journal: J Virol Date: 1990-06 Impact factor: 5.103

9. Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein.

Authors: S Fennewald; V van Santen; E Kieff
Journal: J Virol Date: 1984-08 Impact factor: 5.103

10. Expression of a nuclear and a cytoplasmic Epstein-Barr virus early antigen after DNA transfer: cooperation of two distant parts of the genome for expression of the cytoplasmic antigen.

Authors: K Takaki; A Polack; G W Bornkamm
Journal: Proc Natl Acad Sci U S A Date: 1984-07 Impact factor: 11.205