Literature DB >> 6310507

The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues.

P A Cload, D W Hutchinson.   

Abstract

Substituted methylene diphosphonates are effective inhibitors of the RNA polymerase of influenza A virus causing 50% inhibition of the polymerase activity when they are present in the concentration range 10-85 microM. The inhibitory power of the methylene diphosphonates appears to be related to their ability to chelate with metal ions.

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Year:  1983        PMID： 6310507      PMCID： PMC326301          DOI： 10.1093/nar/11.16.5621

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  8 in total

1.  Measurement of protein-binding phenomena by gel filtration.

Authors:  J P HUMMEL; W J DREYER
Journal:  Biochim Biophys Acta       Date:  1962-10-08

2.  Fowl plaque virus replication in mammalian cell-avian erythrocyte heterokaryons: studies concerning the actinomycin D and ultra-violet light sensitive phase in influenza virus replication.

Authors:  D C Kelly; N J Dimmock
Journal:  Virology       Date:  1974-09       Impact factor: 3.616

3.  Inhibition of the particle-associated RNA-dependent RNA polymerase activity of influenza viruses by chelating agents.

Authors:  J S Oxford; D D Perrin
Journal:  J Gen Virol       Date:  1974-04       Impact factor: 3.891

4.  Influenza RNA transcriptase inhibitors: studies in vitro and in vivo.

Authors:  J S Oxford; D D Perrin
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

5.  Viral chemotherapy: antiviral actions of metal ions and metal-chelating agents.

Authors:  D D Perrin; H Stünzi
Journal:  Pharmacol Ther       Date:  1981       Impact factor: 12.310

6.  The effect of pyrophosphate analogues on influenza virus RNA polymerase and influenza virus multiplication.

Authors:  S Stridh; E Helgstrand; B Lannerö; A Misiorny; G Stening; B Oberg
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

7.  Multiple forms of DNA polymerase in mouse myeloma.

Authors:  A Matsukage; E W Bohn; S H Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205

8.  Polypeptide composition of Influenza B viruses and enzymes associated with the purified virus particles.

Authors:  J S Oxford
Journal:  J Virol       Date:  1973-10       Impact factor: 5.103
  8 in total
  1 in total

1.  The antiviral activity of tetrazole phosphonic acids and their analogues.

Authors:  D W Hutchinson; M Naylor
Journal:  Nucleic Acids Res       Date:  1985-12-09       Impact factor: 16.971
  1 in total

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