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Literature DB >> 6310286

Lead activates calmodulin sensitive processes.

Abstract

The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

Entities: Chemical Gene

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Year: 1983 PMID： 6310286 DOI： 10.1016/0024-3205(83)90757-9

Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037

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Cited

18 in total

Review 1. Molecular mechanisms of lead neurotoxicity.

Authors: J Bressler; K A Kim; T Chakraborti; G Goldstein
Journal: Neurochem Res Date: 1999-04 Impact factor: 3.996

2. Lead reduces depolarization-induced calcium entry in cultured DRG neurons without crossing the cell membrane: fura-2 measurements.

Authors: R Domann; L Wunder; D Büsselberg
Journal: Cell Mol Neurobiol Date: 1997-06 Impact factor: 5.046

Review 3. Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Authors: Rakshya Gorkhali; Kenneth Huang; Michael Kirberger; Jenny J Yang
Journal: Metallomics Date: 2016-06-01 Impact factor: 4.526

Review 4. Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models.

Authors: Angelica Rocha; Keith A Trujillo
Journal: Neurotoxicology Date: 2019-03-02 Impact factor: 4.294

Lead activates calmodulin sensitive processes.

Review 1. Molecular mechanisms of lead neurotoxicity.

2. Lead reduces depolarization-induced calcium entry in cultured DRG neurons without crossing the cell membrane: fura-2 measurements.

Review 3. Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Review 4. Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models.

5. Toxicokinetic study of rat intestinal brush border membrane enzymes following in vitro exposure to lead and vanadium.

Review 6. Molecular and ionic mimicry and the transport of toxic metals.

7. The interaction of aluminum and other metal ions with calcium-calmodulin-dependent phosphodiesterase.

8. Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae.

Review 9. Chronic low-level lead exposure. Its role in the pathogenesis of hypertension.

10. Metal toxicity and opportunistic binding of Pb(2+) in proteins.