Literature DB >> 6309890

Pituitary and adrenal responses to the anti-progesterone and anti-glucocorticoid steroid RU 486 in primates.

D L Healy, G P Chrousos, H M Schulte, R F Williams, P W Gold, E E Baulieu, G D Hodgen.   

Abstract

RU 486 is a synthetic steroid with anti-progesterone and anti-glucocorticoid properties. While studying its acute effects on pituitary hormone secretion in cynomolgus monkeys, we found that RU 486 inhibited PRL secretion induced by an estrogen-progesterone synergy (P less than 0.025). By contrast, plasma levels of ACTH, arginine vasopressin and cortisol increased following RU 486 administration (P less than 0.05). Plasma FSH, LH, GH and TSH were unaffected by RU 486 treatment. Our findings suggest potential diagnostic and therapeutic applications of RU 486.

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Year:  1983        PMID： 6309890     DOI： 10.1210/jcem-57-4-863

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  8 in total

1.  The antiprogesterones are coming: menses induction, abortion, and labour?

Authors:  D L Healy; H M Fraser
Journal:  Br Med J (Clin Res Ed)       Date:  1985-02-23

2.  Enhancement of the ACTH response to human CRH by pretreatment with the antiglucocorticoid RU-486.

Authors:  A R Hermus; G F Pieters; G J Pesman; A G Smals; T J Benraad; P W Kloppenborg
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

3.  Glucocorticoid receptors are involved in the regulation of pulsatile urea excretion in toadfish.

Authors:  M D McDonald; C M Wood; M Grosell; P J Walsh
Journal:  J Comp Physiol B       Date:  2004-10-28       Impact factor: 2.200

4.  Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups.

Authors:  V Joseph; L M Niane; A Bairam
Journal:  Neuroscience       Date:  2012-01-28       Impact factor: 3.590

Review 5.  Mifegyne (mifepristone), a new antiprogestagen with potential therapeutic use in human fertility control.

Authors:  B Couzinet; G Schaison
Journal:  Drugs       Date:  1988-03       Impact factor: 9.546

6.  The effect of chronic cortisol elevation on urea metabolism and excretion in the rainbow trout (Oncorhynchus mykiss).

Authors:  M D McDonald; C M Wood
Journal:  J Comp Physiol B       Date:  2003-10-28       Impact factor: 2.200

7.  Mifepristone Increases Thyroid Hormone Requirements in Patients With Central Hypothyroidism: A Multicenter Study.

Authors:  Francisco J Guarda; James Findling; Kevin C J Yuen; Maria Fleseriu; Lisa B Nachtigall
Journal:  J Endocr Soc       Date:  2019-07-05

8.  Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI-induced hypogonadism?

Authors:  Rastafa I Geddes; Amita Kapoor; Kentaro Hayashi; Ryan Rauh; Marlyse Wehber; Quinn Bongers; Alex D Jansen; Icelle M Anderson; Gabrielle Farquhar; Sivan Vadakkadath-Meethal; Toni E Ziegler; Craig S Atwood
Journal:  Endocrinol Diabetes Metab       Date:  2021-03-18
  8 in total

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