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Literature DB >> 6309648

Cytogenetic and biochemical investigations on fibroblast cultures and clones with one and two active X chromosomes of a 69,XXY triploidy.

W Vogel, T Trautmann, H Hörler, S Pentz.

Abstract

Bromodeoxyuridine replication patterns showed that fibroblasts from a 69,XXY triploidy carried either one or two early replicating X chromosomes. The activity of alpha-galactosidase A measured in single cells fell into two classes with a ratio of 1:2. Dilute plating produced clones of both types with the activity of alpha-galactosidase A corresponding to the number of active X chromosomes. To our knowledge, this is the first report on clones of a triploidy with different numbers of active X chromosomes, and on a gene-dosage effect of an X-linked gene using triploid cells with one active X as control.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1983 PMID： 6309648 DOI： 10.1007/bf00279402

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

13 in total

1. Nuclear sex in triploid XXY human cells.

Authors: D G HARNDEN
Journal: Lancet Date: 1961-08-26 Impact factor: 79.321

2. Gene dosage effect in human triploid fibroblasts.

Authors: C Junien; H Rubinson; J C Dreyfus; M C Meinenhofer; N Ravise; J Boué; A Boué
Journal: Hum Genet Date: 1976-07-07 Impact factor: 4.132

3. Demonstration of replication patterns corresponding to G- and R-type banding of chromosomes after partial synchronization of cell cultures with BrdU or dT surplus.

Authors: W Schempp; I Sigwarth; W Vogel
Journal: Hum Genet Date: 1978-12-18 Impact factor: 4.132

4. Correlation between cell enlargement and nucleic acid and protein content of HeLa cells in unbalanced growth produced by inhibitors of DNA synthesis.

Authors: L S Cohen; G P Studzinski
Journal: J Cell Physiol Date: 1967-06 Impact factor: 6.384

5. Chromosome studies in selected spontaneous abortions. Polyploidy in man.

Authors: D H Carr
Journal: J Med Genet Date: 1971-06 Impact factor: 6.318

6. DNA replication patterns of human chromosomes from fibroblasts and amniotic fluid cells revealed by a Giemsa staining technique.

Authors: J T Epplen; J W Siebers; W Vogel
Journal: Cytogenet Cell Genet Date: 1975

7. Late replicating X chromosomes in human triploidy.

Authors: P A Jacobs; A M Matsuyama; I M Buchanan; C Wilson
Journal: Am J Hum Genet Date: 1979-07 Impact factor: 11.025

8. Comparison of thymidine, fluorodeoxyuridine, hydroxyurea, and methotrexate blocking at the G1/S phase transition of the cell cycle, studied by replication patterns.

Authors: W Vogel; W Schempp; I Sigwarth
Journal: Hum Genet Date: 1978-12-18 Impact factor: 4.132

9. Fabry's disease: alpha-galactosidase deficiency.

Authors: J A Kint
Journal: Science Date: 1970-02-27 Impact factor: 47.728

10. Rapid, one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry.

Authors: H A Crissman; J A Steinkamp
Journal: Cytometry Date: 1982-09

4 in total