Literature DB >> 6309554

Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark.

L Santamaria, A Bianchi, A Arnaboldi, L Andreoni, P Bermond.   

Abstract

The carotenoids beta-carotene (C) and canthaxanthine (CX), with and without pro-vitamin A activity, respectively, when perorally administered to mice, markedly prevent benzo(a)pyrene photocarcinogenic enhancement (BP-PCE), continue to block such BP-PCE and protect significantly against BP carcinogenesis in mice maintained in the dark. These results appear relevant to both the pathogenesis of chemical carcinogenesis and rational programs of skin cancer prevention in humans.

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Year:  1983        PMID： 6309554     DOI： 10.1007/bf01989795

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Effects of beta-carotene on ultraviolet induced cancer formation in the hairless mouse skin.

Authors:  J H Epstein
Journal:  Photochem Photobiol       Date:  1977-02       Impact factor: 3.421

2.  Photocarcinogenesis by methoxypsoralen, neutral red and proflavine.

Authors:  L Santamaria; A Arnaboldi; P Daffara; A Bianchi
Journal:  Boll Chim Farm       Date:  1979-07

3.  Prevention of the benzo(a)pyrene photocarcinogenic effect by beta-carotene and canthaxanthine. Preliminary study.

Authors:  L Santamaria; A Bianchi; A Arnaboldi; L Andreoni
Journal:  Boll Chim Farm       Date:  1980-12

4.  Effects of light on 3,4-benzpyrene carcinogenesis.

Authors:  L Santamaria; G G Giordano; M Alfisi; F Cascione
Journal:  Nature       Date:  1966-05-21       Impact factor: 49.962

5.  Prophylactic and therapeutic actions of supplemental beta-carotene in mice inoculated with C3HBA adenocarcinoma cells: lack of therapeutic action of supplemental ascorbic acid.

Authors:  G Rettura; F Stratford; S M Levenson; E Seifter
Journal:  J Natl Cancer Inst       Date:  1982-07       Impact factor: 13.506

6.  Dietary vitamin A and risk of cancer in the Western Electric study.

Authors:  R B Shekelle; M Lepper; S Liu; C Maliza; W J Raynor; A H Rossof; O Paul; A M Shryock; J Stamler
Journal:  Lancet       Date:  1981-11-28       Impact factor: 79.321

Review 7.  Can dietary beta-carotene materially reduce human cancer rates?

Authors:  R Peto; R Doll; J D Buckley; M B Sporn
Journal:  Nature       Date:  1981-03-19       Impact factor: 49.962
  7 in total
  5 in total

1.  Subcellular distribution of dietary beta-carotene in chick liver.

Authors:  S T Mayne; R S Parker
Journal:  Lipids       Date:  1986-02       Impact factor: 1.880

2.  Dietary vitamin A, beta carotene and risk of epidermoid lung cancer in south-western France.

Authors:  J F Dartigues; F Dabis; N Gros; A Moise; G Bois; R Salamon; J M Dilhuydy; G Courty
Journal:  Eur J Epidemiol       Date:  1990-09       Impact factor: 8.082

Review 3.  Cancer chemoprevention by supplemental carotenoids and synergism with retinol in mastodynia treatment.

Authors:  L A Santamaria; A B Santamaria
Journal:  Med Oncol Tumor Pharmacother       Date:  1990

Review 4.  Free radicals as carcinogens and their quenchers as anticarcinogens.

Authors:  L Santamaria; A Bianchi-Santamaria
Journal:  Med Oncol Tumor Pharmacother       Date:  1991

5.  Carotenoids and retinol: their possible importance in determining longevity of primate species.

Authors:  R G Cutler
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205
  5 in total

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