Literature DB >> 6309514

A type I DNA topoisomerase from Trypanosoma cruzi.

G F Riou, M Gabillot, S Douc-Rasy, A Kayser, M Barrois.   

Abstract

A type I DNA topoisomerase has been isolated from the nuclei of the flagellate Trypanosoma cruzi, using poly(ethylene glycol) fractionation and chromatography on hydroxyapatite and on phosphocellulose. The relaxation activity was ATP-independent, enhanced by Mg2+ and spermidine. The enzyme removed supercoils from negative and positive superhelical DNAs. Topoisomerase activity was associated with a polypeptide of Mr about 65000 as shown by glycerol gradient centrifugation and by electrophoresis on sodium dodecyl sulfate/polyacrylamide gels.

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Year:  1983        PMID： 6309514     DOI： 10.1111/j.1432-1033.1983.tb07592.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  8 in total

1.  ATP-independent type II topoisomerase from trypanosomes.

Authors:  S Douc-Rasy; A Kayser; J F Riou; G Riou
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

Review 2.  DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?

Authors:  A K Larsen; C Gobert
Journal:  Pathol Oncol Res       Date:  1999       Impact factor: 3.201

3.  Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.

Authors:  T A Shapiro
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

4.  An unusual type IB topoisomerase from African trypanosomes.

Authors:  Annette L Bodley; Asit K Chakraborty; Suji Xie; Christian Burri; Theresa A Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-16       Impact factor: 11.205

5.  Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.

Authors:  A L Bodley; T A Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

6.  Inhibition of the reactions catalysed by a type I topoisomerase and catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of the catenating reaction.

Authors:  S Douc-Rasy; A Kayser; G F Riou
Journal:  EMBO J       Date:  1984-01       Impact factor: 11.598

7.  Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.

Authors:  Angela Maria Arenas Velásquez; Willian Campos Ribeiro; Vutey Venn; Silvia Castelli; Mariana Santoro de Camargo; Renata Pires de Assis; Rodrigo Alves de Souza; Aline Rimoldi Ribeiro; Thaís Gaban Passalacqua; João Aristeu da Rosa; Amanda Martins Baviera; Antonio Eduardo Mauro; Alessandro Desideri; Elmo Eduardo Almeida-Amaral; Marcia A S Graminha
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

Review 8.  The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics.

Authors:  Rubem Figueiredo Sadok Menna-Barreto; Solange Lisboa de Castro
Journal:  Biomed Res Int       Date:  2014-03-31       Impact factor: 3.411
  8 in total

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