Literature DB >> 6309330

Botulinum A toxin and tetanus toxin do not affect presynaptic membrane currents in mammalian motor nerve endings.

F Dreyer, A Mallart, J L Brigant.   

Abstract

The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by bath application of BoTx or TeTx at doses which block neuromuscular transmission.

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Year:  1983        PMID： 6309330     DOI： 10.1016/0006-8993(83)90617-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  SNARE proteins contribute to calcium cooperativity of synaptic transmission.

Authors:  B A Stewart; M Mohtashami; W S Trimble; G L Boulianne
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

2.  Ca2+ or Sr2+ partially rescues synaptic transmission in hippocampal cultures treated with botulinum toxin A and C, but not tetanus toxin.

Authors:  M Capogna; R A McKinney; V O'Connor; B H Gähwiler; S M Thompson
Journal:  J Neurosci       Date:  1997-10-01       Impact factor: 6.167

3.  Synaptic activity regulates the abundance and binding of complexin.

Authors:  Rachel T Wragg; Géraldine Gouzer; Jihong Bai; Gianluca Arianna; Timothy A Ryan; Jeremy S Dittman
Journal:  Biophys J       Date:  2015-03-24       Impact factor: 4.033

4.  A study of synchronization of quantal transmitter release from mammalian motor endings by the use of botulinal toxins type A and D.

Authors:  J Molgó; L S Siegel; N Tabti; S Thesleff
Journal:  J Physiol       Date:  1989-04       Impact factor: 5.182

5.  Botulinum toxin type A blocks the morphological changes induced by chemical stimulation on the presynaptic membrane of Torpedo synaptosomes.

Authors:  J Marsal; G Egea; C Solsona; X Rabasseda; J Blasi
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

6.  The effects of in vitro application of purified botulinum neurotoxin at mouse motor nerve terminals.

Authors:  J O Dolly; S Lande; D W Wray
Journal:  J Physiol       Date:  1987-05       Impact factor: 5.182

7.  Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain.

Authors:  B Poulain; L Tauc; E A Maisey; J D Wadsworth; P M Mohan; J O Dolly
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

8.  Differential effects of various secretagogues on quantal transmitter release from mouse motor nerve terminals treated with botulinum A and tetanus toxin.

Authors:  F Dreyer; F Rosenberg; C Becker; H Bigalke; R Penner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-01       Impact factor: 3.000

9.  Facilitation, augmentation and potentiation of transmitter release at frog neuromuscular junctions poisoned with botulinum toxin.

Authors:  M T Lupa; N Tabti
Journal:  Pflugers Arch       Date:  1986-06       Impact factor: 3.657

10.  Distinct sites of action of clostridial neurotoxins revealed by double-poisoning of mouse motor nerve terminals.

Authors:  M Gansel; R Penner; F Dreyer
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657
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