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Literature DB >> 6308994

Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol.

R Ginsburg, M R Bristow, M E Billingham, E B Stinson, J S Schroeder, D C Harrison.

Abstract

We evaluated the effects of isoproterenol in right ventricular papillary muscles derived from normal and failing isolated human hearts. Basal values for the peak force developed, rate of force development (dF/dt), and time to peak tension (TPT) were similar in both groups. Isoproterenol produced a significantly smaller (p less than 0.05) increase in peak force developed and dF/dt in failing papillary muscles. The half equivalent dose (ED50) of isoproterenol was fivefold higher in failing muscle as compared to normal muscle. We conclude that failing cardiac muscle demonstrates decreased responsiveness to beta-receptor mediated stimulation.

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Year: 1983 PMID： 6308994 DOI： 10.1016/0002-8703(83)90698-1

Source DB: PubMed Journal: Am Heart J ISSN： 0002-8703 Impact factor: 4.749

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Cited

28 in total

Review 1. Therapy of idiopathic dilated cardiomyopathy with chronic beta-adrenergic blockade.

Authors: E M Gilbert; J B O'Connell; M R Bristow
Journal: Heart Vessels Suppl Date: 1991

2. Myocardial beta-adrenoceptor density and the distribution of beta 1- and beta 2-adrenoceptor subpopulations in children with congenital heart disease.

Authors: R Kozlik; H H Kramer; H Wicht; A Krian; J Ostermeyer; D Reinhardt
Journal: Eur J Pediatr Date: 1991-04 Impact factor: 3.183

3. The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β₁-adrenergic receptor expression and signaling.

Authors: Samuel Mon-Wei Yu; Pierre-Yves Jean-Charles; Dennis M Abraham; Suneet Kaur; Clarice Gareri; Lan Mao; Howard A Rockman; Sudha K Shenoy
Journal: J Biol Chem Date: 2018-12-11 Impact factor: 5.157

4. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.

Authors: H von der Leyen; U Mende; W Meyer; J Neumann; M Nose; W Schmitz; H Scholz; J Starbatty; B Stein; H Wenzlaff
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1991-07 Impact factor: 3.000

Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol.

Review 1. Therapy of idiopathic dilated cardiomyopathy with chronic beta-adrenergic blockade.

2. Myocardial beta-adrenoceptor density and the distribution of beta 1- and beta 2-adrenoceptor subpopulations in children with congenital heart disease.

3. The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β₁-adrenergic receptor expression and signaling.

4. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.

5. Idiopathic dilated cardiomyopathy.

Review 6. Intracellular calcium in heart failure.

7. The positive inotropic response to milrinone in isolated human and guinea pig myocardium.

8. Additive positive inotropic effects of milrinone, ouabain and calcium in diseased human ventricular myocardium.

9. Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]-nitrendipine binding sites.

10. Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.