Literature DB >> 6308877

Immunocytochemical demonstration of insulin in spontaneous pancreatic islet cell tumors of Fischer rats.

P C Stromberg, F Wilson, C C Capen.   

Abstract

Nineteen spontaneous pancreatic islet cell tumors were studied in 26-month-old control Fischer 344 rats. Seventeen of 19 (89%) tumors demonstrated insulin reactivity using peroxidase-antiperoxidase immunocytochemistry. None of ten tumors had positive glucagon immunoreactivity. Immunocytochemical and ultrastructural observations suggested that spontaneous occurring islet cell tumors of F344 rats were composed exclusively of beta cells.

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Year:  1983        PMID： 6308877     DOI： 10.1177/030098588302000305

Source DB:  PubMed          Journal:  Vet Pathol        ISSN： 0300-9858            Impact factor:   2.221


  4 in total

1.  Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies.

Authors:  Christopher Koivisto; Gordon P Flake; Holly Kolenda-Roberts; Tiwanda Masinde; Grace E Kissling; Robert C Sills; Mark J Hoenerhoff
Journal:  Toxicol Pathol       Date:  2012-04-03       Impact factor: 1.902

2.  Insulinoma and squamous cell carcinoma with peripheral polyneuropathy in an aged Sprague-Dawley rat.

Authors:  Hibret A Adissu; Patricia V Turner
Journal:  J Am Assoc Lab Anim Sci       Date:  2010-11       Impact factor: 1.232

Review 3.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.

Authors:  Annamaria Brändli-Baiocco; Emmanuelle Balme; Marc Bruder; Sundeep Chandra; Juergen Hellmann; Mark J Hoenerhoff; Takahito Kambara; Christian Landes; Barbara Lenz; Mark Mense; Susanne Rittinghausen; Hiroshi Satoh; Frédéric Schorsch; Frank Seeliger; Takuji Tanaka; Minoru Tsuchitani; Zbigniew Wojcinski; Thomas J Rosol
Journal:  J Toxicol Pathol       Date:  2018-07-28       Impact factor: 1.628

4.  Spontaneous well-differentiated pancreatic islet cell carcinoma with vascular invasion in a male F344 rat.

Authors:  Shiori Fujiwara; Yuko Yamaguchi; Tsubasa Saito; Tomomi Nakazawa; Kazutoshi Tamura
Journal:  J Toxicol Pathol       Date:  2021-10-08       Impact factor: 1.628
  4 in total

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