Literature DB >> 6308759

Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid.

C E Brinckerhoff, J W Coffey, A C Sullivan.   

Abstract

Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.

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Year:  1983        PMID： 6308759     DOI： 10.1126/science.6308759

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Retinoids inhibit the respiratory burst and degranulation of stimulated human polymorphonuclear leukocytes.

Authors:  R Fumarulo; M Conese; S Riccardi; D Giordano; P Montemurro; M Colucci; N Semeraro
Journal:  Agents Actions       Date:  1991-11

2.  Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma.

Authors:  S Nagpal; J Cai; T Zheng; S Patel; R Masood; G Y Lin; S Friant; A Johnson; D L Smith; R A Chandraratna; P S Gill
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

Review 3.  Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms.

Authors:  D J Schroen; C E Brinckerhoff
Journal:  Gene Expr       Date:  1996

4.  Retinoid modulation of collagenase production by adherent human mononuclear cells in culture.

Authors:  A Ohta; J S Louie; J Uitto
Journal:  Ann Rheum Dis       Date:  1987-05       Impact factor: 19.103

Review 5.  Vitamin effects on the immune system: vitamins A and D take centre stage.

Authors:  J Rodrigo Mora; Makoto Iwata; Ulrich H von Andrian
Journal:  Nat Rev Immunol       Date:  2008-09       Impact factor: 53.106

6.  In vitro inhibition of arachidonic acid metabolism by two novel retinoid analogs.

Authors:  C Fiedler-Nagy; B H Wittreich; M A Carey
Journal:  Agents Actions       Date:  1989-06

Review 7.  Could retinoids be a potential treatment for rheumatic diseases?

Authors:  Yoshishige Miyabe; Chie Miyabe; Toshihiro Nanki
Journal:  Rheumatol Int       Date:  2014-06-18       Impact factor: 2.631

8.  Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.

Authors:  Dongchun Liang; Aijun Zuo; Hui Shao; Willi K Born; Rebecca L O'Brien; Henry J Kaplan; Deming Sun
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-05-01       Impact factor: 4.799

9.  Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.

Authors:  Kevin M Elias; Arian Laurence; Todd S Davidson; Geoffrey Stephens; Yuka Kanno; Ethan M Shevach; John J O'Shea
Journal:  Blood       Date:  2007-10-19       Impact factor: 22.113

Review 10.  Isotretinoin. A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders.

Authors:  A Ward; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-07       Impact factor: 9.546
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