Literature DB >> 6308169

Specific binding of [3H]rauwolscine to alpha 2-adrenoceptors in rat cerebral cortex: comparison between crude and synaptosomal plasma membranes.

L Diop, J P Dausse, P Meyer.   

Abstract

[3H]Rauwolscine, a specific, potent, radiolabelled alpha 2-antagonist, binds to distinct high- and low-affinity alpha 2-adrenoceptors in crude membrane preparations of the rat cerebral cortex. The concentration of high-affinity alpha 2-adrenoceptors was increased by addition of sodium ions or guanylnucleotides. In synaptosomal plasma membrane preparations, only the low-affinity component was found. Neither sodium or guanylnucleotides caused any increase in the concentration of these low-affinity receptors for [3H]rauwolscine.

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Year:  1983        PMID： 6308169     DOI： 10.1111/j.1471-4159.1983.tb04798.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  8 in total

1.  [3H]L-654,284 as a probe of the central alpha 2 adrenoceptor.

Authors:  W C Randall; J R Huff; J P Vacca; J P Guare; R Chen; A Rosegay; J J Baldwin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-07       Impact factor: 3.000

2.  Changes in central alpha-adrenoceptors and noradrenaline content after high sodium intake in Sabra salt-sensitive and salt-resistant rats.

Authors:  A Parini; L Diop; D Laude; D Ben-Ishay; J P Dausse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-06       Impact factor: 3.000

3.  [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species.

Authors:  C B Neylon; R J Summers
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

4.  [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification.

Authors:  A C MacKinnon; A T Kilpatrick; B A Kenny; M Spedding; C M Brown
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

5.  Heterogeneity of alpha 2-adrenoceptors in rat cortex but not human platelets can be defined by 8-OH-DPAT, RU 24969 and methysergide.

Authors:  C M Brown; A C MacKinnon; J C McGrath; M Spedding; A T Kilpatrick
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

6.  Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist.

Authors:  A D Michel; D N Loury; R L Whiting
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

7.  Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: role of disulfide and sulfhydryl groups.

Authors:  T A Reader; R Brière; L Grondin
Journal:  Neurochem Res       Date:  1986-01       Impact factor: 3.996

8.  Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: competition studies with [3H]prazosin and [3H]idazoxan.

Authors:  T A Reader; R Brière; L Grondin
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575
  8 in total

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