Literature DB >> 6308064

Calcium pyrophosphate dihydrate (CPPD) deposition in ochronotic arthropathy.

J McClure, P S Smith, A A Gramp.   

Abstract

The post-mortem examination of an unsuspected case of alkaptonuria revealed extensive ochronosis. Histological examination of undecalcified sections of tracheal, costal, femoral and patellar cartilage revealed, in addition to ochronotic pigment, extensive calcium pyrophosphate dihydrate (CPPD) deposition. Similar deposits were present in intervertebral discs and were related to ossification of the discs resulting in partial or complete ankylosis. The calcific deposits were present around chondrocytes in the articular cartilage and this may be an important factor in the initiation of the osteoarthrotic process which characterises ochronotic arthropathy as it affects large diarthrodial joints.

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Year:  1983        PMID： 6308064      PMCID： PMC498417          DOI： 10.1136/jcp.36.8.894

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  14 in total

1.  Studies on the pathogenesis of ochronotic arthropathy.

Authors:  W M O'BRIEN; W G BANFIELD; L SOKOLOFF
Journal:  Arthritis Rheum       Date:  1961-04

2.  Alkaptonuric arthritis.

Authors:  A J HARROLD
Journal:  J Bone Joint Surg Br       Date:  1956-05

3.  Pseudogout in ochronosis. Report of a case.

Authors:  R I Rynes; J L Sosman; D E Holdsworth
Journal:  Arthritis Rheum       Date:  1975 Jan-Feb

4.  The identification of particulate matter in biological tissues and fluids.

Authors:  P R Crocker; P A Dieppe; G Tyler; S K Chapman; D A Willoughby
Journal:  J Pathol       Date:  1977-01       Impact factor: 7.996

5.  Hereditary ochronosis; pathologic changes observed in two necropsied cases.

Authors:  L LICHTENSTEIN; L KAPLAN
Journal:  Am J Pathol       Date:  1954 Jan-Feb       Impact factor: 4.307

6.  Combined anatomical and radiological study of the hip-joint in alcaptonuric arthropathy.

Authors:  U Steiger; R Lagier
Journal:  Ann Rheum Dis       Date:  1972-09       Impact factor: 19.103

7.  Ochronotic densification.

Authors:  E G Bywaters; J Dorling; J Sutor
Journal:  Ann Rheum Dis       Date:  1970-09       Impact factor: 19.103

8.  Ochronotic arthropathy. A review with four case reports.

Authors:  F H Laskar; K D Sargison
Journal:  J Bone Joint Surg Br       Date:  1970-11

9.  Natural history of degenerative joint disease in small laboratory animals. IV. Degenerative joint disease in the laboratory rat.

Authors:  G E JAY; L SOKOLOFF
Journal:  AMA Arch Pathol       Date:  1956-08

10.  Pyrophosphate arthropathy in hypophosphatasia.

Authors:  A W Eade; A J Swannell; N Williamson
Journal:  Ann Rheum Dis       Date:  1981-04       Impact factor: 19.103
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  4 in total

1.  Alkaptonuria associated with degenerative collagenous palmar plaques.

Authors:  Biju Vasudevan; M P S Sawhney; S Radhakrishnan
Journal:  Indian J Dermatol       Date:  2009-07       Impact factor: 1.494

Review 2.  Alkaptonuria.

Authors:  Jemma B Mistry; Marwan Bukhari; Adam M Taylor
Journal:  Rare Dis       Date:  2013-12-18

3.  Low back pain and ochronosis.

Authors:  L Sakkas; B Thouas; P Smyrnis; E Vlahos
Journal:  Int Orthop       Date:  1987       Impact factor: 3.075

Review 4.  Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review.

Authors:  L Ventura-Ríos; C Hernández-Díaz; L Gutiérrez-Pérez; A Bernal-González; R Pichardo-Bahena; A L Cedeño-Garcidueñas; C Pineda
Journal:  Clin Rheumatol       Date:  2014-03-20       Impact factor: 2.980
  4 in total

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