Literature DB >> 6307737

Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors?

E Borda, L Sterin-Borda, M F Gimeno, M Lazzari, A L Gimeno.   

Abstract

The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitors of cyclo-oxygenase and prostacyclinsynthetase.

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Year:  1983        PMID： 6307737     DOI： 10.1007/bf01990425

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  The importance of phospholipase-A2 in prostaglandin biosynthesis.

Authors:  R J Flower; G J Blackwell
Journal:  Biochem Pharmacol       Date:  1976-02-01       Impact factor: 5.858

2.  Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens.

Authors:  E S Borda; M C Agostini; M F Gimeno; A L Gimeno
Journal:  Pharmacol Res Commun       Date:  1981-05

3.  Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens.

Authors:  E Borda; M del C Agostini; M F Gimeno; A L Gimeno
Journal:  Pharmacol Res Commun       Date:  1981-11

Review 4.  Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.

Authors:  S Moncada
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

5.  A structure-activity study on the influence of phenolic compounds and bioflavonoids on rat renal prostaglandin synthetase.

Authors:  J Baumann; F von Bruchhausen; G Wurm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

6.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

7.  Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2).

Authors:  E S Borda; M C Agostini; N Sterin-Speziale; M F Gimeno; A L Gimeno
Journal:  Prostaglandins       Date:  1979-12

8.  Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs.

Authors:  L Sterin-Borda; E S Borda; M F Gimeno; M A Lazzari; E del Castillo; A L Gimeno
Journal:  Diabetologia       Date:  1982-01       Impact factor: 10.122

9.  Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries.

Authors:  M F Gimeno; L Sterin-Borda; E S Borda; M A Lazzari; A L Gimeno
Journal:  Prostaglandins       Date:  1980-06

10.  Stimulation of prostaglandin E2-synthesis by noradrenaline in primary cell cultures from rabbit splenic pulpa is mediated by atypical alpha-adrenoceptors.

Authors:  R Brückner-Schmidt; R Jackisch; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-02       Impact factor: 3.000
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  1 in total

1.  Hypersensitivity to methoxamine in atria isolated from streptozotocin-induced diabetic rats.

Authors:  L Canga; L Sterin-Borda
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739
  1 in total

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