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Literature DB >> 6307710

Evidence for an intramuscular depot of the cholinesterase inhibitor soman in the rat.

Abstract

Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soman-poisoned rats treated with HI-6 again showed spontaneous failure of NMT when tested repeatedly in vitro. In vivo pretreatment with a soman simulator prevented reinhibition in vitro. The results are indicative of a simulator-sensitive soman depot in muscles.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6307710 DOI： 10.1016/0014-2999(83)90504-6

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

6 in total

4. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.

Authors: J G Clement; J D Shiloff; C Gennings
Journal: Arch Toxicol Date: 1987 Impact factor: 5.153

5. Pharmacokinetics of the soman simulant 1,2,2-trimethylpropyl dimethylphosphinate (PDP) in rats.

Authors: H P Benschop; H C Wesselman
Journal: Arch Toxicol Date: 1989 Impact factor: 5.153

6. Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2.

Authors: Z Grubic; A Tomazic
Journal: Arch Toxicol Date: 1989 Impact factor: 5.153

6 in total

Evidence for an intramuscular depot of the cholinesterase inhibitor soman in the rat.

1. Detoxification of soman in the perfused rat liver: quantitative uptake and stereoisomer metabolism.

2. Stereoselectivity of enzymes involved in toxicity and detoxification of soman.

3. Effects of CBDP and MEPQ on the toxicity and distribution of [3H]-soman in mice.

4. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.

5. Pharmacokinetics of the soman simulant 1,2,2-trimethylpropyl dimethylphosphinate (PDP) in rats.

6. Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2.