Literature DB >> 6306919

Neutralization of poliovirus by antibody-mediated polymerization.

P Brioen, D Dekegel, A Boeyé.   

Abstract

The neutralization of type 1 poliovirus by a monoclonal antibody was studied. The antibody caused polymerization of the virions as observed by sucrose gradient centrifugation and electron microscopy. Dimers, trimers, and higher polymers were formed. No antibody was found in association with the monomeric virions remaining after neutralization, which retained full infectivity. The specific infectivities of dimers, trimers, and higher polymers decreased in that order.

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Year:  1983        PMID： 6306919     DOI： 10.1016/0042-6822(83)90159-9

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  24 in total

1.  Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Authors:  Cristina Herrera; Jacqueline M Tremblay; Charles B Shoemaker; Nicholas J Mantis
Journal:  J Biol Chem       Date:  2015-09-22       Impact factor: 5.157

2.  Antibodies to the trypsin cleavage peptide VP8 neutralize rotavirus by inhibiting binding of virions to target cells in culture.

Authors:  F M Ruggeri; H B Greenberg
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

3.  Structure of a neutralizing antibody bound monovalently to human rhinovirus 2.

Authors:  E A Hewat; T C Marlovits; D Blaas
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

4.  Wall effects in sucrose density gradient centrifugation of viruses.

Authors:  A Boeyé; A De Rees
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

5.  Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragments.

Authors:  R J Colonno; P L Callahan; D M Leippe; R R Rueckert; J E Tomassini
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

6.  Evidence for at least two dominant neutralization antigens on human rhinovirus 14.

Authors:  B Sherry; R Rueckert
Journal:  J Virol       Date:  1985-01       Impact factor: 5.103

7.  A monoclonal antibody that neutralizes poliovirus by cross-linking virions.

Authors:  A A Thomas; P Brioen; A Boeyé
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

8.  Relationship between poliovirus neutralization and aggregation.

Authors:  A A Thomas; R Vrijsen; A Boeyé
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

9.  Neutralization of poliovirus by polyclonal antibodies requires binding of a single IgG molecule per virion.

Authors:  K Wetz; P Willingmann; H Zeichhardt; K O Habermehl
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

10.  Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity.

Authors:  Lise Schotte; Mike Strauss; Bert Thys; Hadewych Halewyck; David J Filman; Mihnea Bostina; James M Hogle; Bart Rombaut
Journal:  J Virol       Date:  2014-02-05       Impact factor: 5.103
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