Literature DB >> 6306581

Blocked 5'-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumor drug 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA).

B Marshall, R K Ralph, R Hancock.   

Abstract

Comparison of the sensitivity of DNA isolated from untreated and mAMSA-treated PY815 mouse mastocytoma cells to hydrolysis by E.coli 3'-exonuclease III and phage lambda or phage T7 5'-exonucleases show that the fragments of chromosomal DNA produced by mAMSA treatment have free 3'-OH termini and blocked 5'-termini.

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Year:  1983        PMID： 6306581      PMCID： PMC326039          DOI： 10.1093/nar/11.12.4251

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  17 in total

1.  Induction of limited DNA damage by the antitumor agent Cain's acridine.

Authors:  N B Furlong; J Sato; T Brown; F Chavez; R B Hurlbert
Journal:  Cancer Res       Date:  1978-05       Impact factor: 12.701

Review 2.  DNA modification and cancer.

Authors:  M J Waring
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

3.  Filter-binding assay for covalent DNA-protein complexes: adenovirus DNA-terminal protein complex.

Authors:  D H Coombs; G D Pearson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

Review 4.  DNA topoisomerases.

Authors:  M Gellert
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

5.  On the mechanism of action of 4'-[(9-acridinyl)-amino] methanesulphon-m-anisidide.

Authors:  R K Ralph
Journal:  Eur J Cancer       Date:  1980-05       Impact factor: 9.162

6.  DNA double-stranded breaks in mammalian cells after exposure to intercalating agents.

Authors:  W E Ross; M O Bradley
Journal:  Biochim Biophys Acta       Date:  1981-06-26

7.  Cell-cycle-specific chromosome damage following treatment of cultured Chinese hamster cells with 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide-HCl.

Authors:  L L Deaven; M S Oka; R A Tobey
Journal:  J Natl Cancer Inst       Date:  1978-05       Impact factor: 13.506

8.  Qualitative and quantitative aspects of intercalator-induced DNA strand breaks.

Authors:  W E Ross; D Glaubiger; K W Kohn
Journal:  Biochim Biophys Acta       Date:  1979-03-28

9.  Leukaemia virus infection promotes fibroblast transformation by normal BALB/c mouse DNA.

Authors:  V Krump-Konvalinkova; K J van den Berg
Journal:  Nature       Date:  1980-09-25       Impact factor: 49.962

10.  Protein-associated DNA breaks in cells treated with adriamycin or ellipticine.

Authors:  W E Ross; D L Glaubiger; K W Kohn
Journal:  Biochim Biophys Acta       Date:  1978-06-22
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  2 in total

1.  Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

Authors:  E M Nelson; K M Tewey; L F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

2.  Loss of viability and induction of DNA damage in human leukemic myeloblasts and lymphocytes by m-AMSA.

Authors:  L W Brox; A Belch; A Ng; E Pollock
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333
  2 in total

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