Literature DB >> 6306488

Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery.

M Endoh, N Taira.   

Abstract

In the isolated canine mesenteric artery relaxation caused by nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester; SG-75] in the presence of noradrenaline was accompanied by a concomitant elevation of cGMP level, whilst the cAMP level was not changed by the drug. The relaxation and cGMP level after the administration of nicorandil showed a good correlation. In this respect nicorandil is very similar to nitrogen oxide-containing vasodilators.

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Year:  1983        PMID： 6306488     DOI： 10.1007/bf00508349

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  15 in total

1.  Effect of 2-nicotinamidethyl nitrate (SG 75) on coronary circulation.

Authors:  Y Uchida; N Yoshimoto; S Murao
Journal:  Jpn Heart J       Date:  1978-01

2.  Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens.

Authors:  J Diamond; R A Janis
Journal:  Nature       Date:  1978-02-02       Impact factor: 49.962

3.  Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells and on adrenergic transmission in the guinea-pig and porcine mesenteric arteries.

Authors:  T Itoh; K Furukawa; M Kajiwara; K Kitamura; H Suzuki; Y Ito; H Kuriyama
Journal:  J Pharmacol Exp Ther       Date:  1981-07       Impact factor: 4.030

4.  Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle.

Authors:  W R Kukovetz; S Holzmann; A Wurm; G Pöch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

5.  Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle.

Authors:  M Endoh; S Yamashita; N Taira
Journal:  J Pharmacol Exp Ther       Date:  1982-06       Impact factor: 4.030

6.  Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters.

Authors:  K L Axelsson; R G Andersson; J E Wikberg
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1981-10

7.  Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

Authors:  C A Gruetter; D Y Gruetter; J E Lyon; P J Kadowitz; L J Ignarro
Journal:  J Pharmacol Exp Ther       Date:  1981-10       Impact factor: 4.030

8.  Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ.

Authors:  M Maruyama; K Satoh; N Taira
Journal:  Arch Int Pharmacodyn Ther       Date:  1982-08

9.  Pharmacodynamic and metabolism studies on a new coronary vasodilator, N-(2-hydroxyethyl) nicotinamide nitrate (SG-75).

Authors:  K Sakai; Y Ohba; M Akima; H Kamiyama; Y Hinohara; H Nakano
Journal:  Jpn J Pharmacol       Date:  1980-12

10.  Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries.

Authors:  K Furukawa; T Itoh; M Kajiwara; K Kitamura; H Suzuki; Y Ito; H Kuriyama
Journal:  J Pharmacol Exp Ther       Date:  1981-07       Impact factor: 4.030
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  18 in total

1.  Contribution of cyclic GMP formation to KRN2391-induced relaxation in coronary artery of the pig.

Authors:  Y Jinno; H Kasai; H Ohta; K Nishikori; H Fukushima; N Ogawa
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

2.  Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog.

Authors:  H Yamada; F Yoneyama; K Satoh; N Taira
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

3.  Nitroglycerine- and isoprenaline-induced vasodilatation: assessment from the actions of cyclic nucleotides.

Authors:  T Itoh; Y Kanmura; H Kuriyama; T Sasaguri
Journal:  Br J Pharmacol       Date:  1985-02       Impact factor: 8.739

4.  Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.

Authors:  T Fujiwara; J A Angus
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

5.  Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.

Authors:  F Yoneyama; K Satoh; N Taira
Journal:  Cardiovasc Drugs Ther       Date:  1990-08       Impact factor: 3.727

6.  Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man.

Authors:  G G Belz; J Matthews; J Heinrich; G Wagner
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

7.  The effect of Nicorandil on chronic cerebral vasospasm.

Authors:  T Matsui; T Nagafuji; K Tsutsumi; H Uchida; T Miyauchi; T Asano
Journal:  Acta Neurochir (Wien)       Date:  1994       Impact factor: 2.216

8.  Hyperpolarization induced by K+ channel openers inhibits Ca2+ influx and Ca2+ release in coronary artery.

Authors:  T Yanagisawa; T Yamagishi; Y Okada
Journal:  Cardiovasc Drugs Ther       Date:  1993-08       Impact factor: 3.727

9.  Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear.

Authors:  M D Randall; T M Griffith
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

10.  Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.

Authors:  D R Harder; P Dernbach; A Waters
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808
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